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Mouse Anti-FSTL3 Recombinant Antibody (2E7) (CBMAB-A3186-LY)

The product is antibody recognizes FSTL3. The antibody 2E7 immunoassay techniques such as: ELISA.
See all FSTL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
FSTL3 (NP_005851.1, 27 a.a. ~ 263 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
follistatin-like 3 (secreted glycoprotein)
Introduction
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq]
Entrez Gene ID
10272
UniProt ID
O95633
Alternative Names
FLRG; FSRP
Function
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
Biological Process
Adrenal gland development Source: Ensembl
Cell differentiation Source: GO_Central
Cellular response to metal ion Source: Ensembl
Hematopoietic progenitor cell differentiation Source: UniProtKB
Kidney development Source: Ensembl
Lung development Source: Ensembl
Male gonad development Source: Ensembl
Negative regulation of activin receptor signaling pathway Source: UniProtKB
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of osteoclast differentiation Source: UniProtKB
Negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway Source: UniProtKB
Ossification Source: UniProtKB-KW
Positive regulation of cell-cell adhesion Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of BMP signaling pathway Source: GO_Central
Regulation of transcription by RNA polymerase II Source: UniProtKB
Spermatogenesis Source: Ensembl
Cellular Location
Isoform 1: Secreted
Isoform 2: Nucleus. Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
Involvement in disease
A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1.

Li, X., Zhang, H., Ma, X., Wang, Y., Han, X., Yang, Y., ... & Bao, Y. (2023). FSTL3 is highly expressed in adipose tissue of individuals with overweight or obesity and is associated with inflammation. Obesity, 31(1), 171-183.

Li, C. H., Fang, C. Y., Chan, M. H., Chen, C. L., Chang, Y. C., & Hsiao, M. (2023). The cytoplasmic expression of FSTL3 correlates with colorectal cancer progression, metastasis status and prognosis. Journal of Cellular and Molecular Medicine.

Liu, Y. J., Li, J. P., Zhang, Y., Nie, M. J., Zhang, Y. H., Liu, S. L., & Zou, X. (2021). FSTL3 is a prognostic biomarker in gastric cancer and is correlated with M2 macrophage infiltration. OncoTargets and therapy, 14, 4099.

Sun, F., Sun, P., Yang, X., Hu, L., Gao, J., & Tian, T. (2021). Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway. Aging (Albany NY), 13(18), 22528.

Brown, M. L., Lopez, A., Meyer, N., Richter, A., & Thompson, T. B. (2021). FSTL3-Neutralizing antibodies enhance glucose-responsive insulin secretion in dysfunctional male mouse and human islets. Endocrinology, 162(10).

He, J., Liu, Q., Yu, S., Lei, M., Liu, J., Di, R., ... & Chu, M. (2021). Expression and functional analysis of the Follistatin‐like 3 (FSTL3) gene in the sheep ovary during the oestrous cycle. Reproduction in Domestic Animals, 56(3), 427-436.

Li, J., Shen, J., Qin, L., Lu, D., & Ding, E. (2021). LBX2-AS1 activates FSTL3 by binding to transcription factor RARα to foster proliferation, migration, and invasion of thyroid cancer. Frontiers in Genetics, 2255.

Gao, L., Chen, X., Wang, Y., & Zhang, J. (2020). Up-regulation of FSTL3, regulated by lncRNA DSCAM-AS1/miR-122-5p Axis, promotes proliferation and migration of non-small cell lung Cancer cells. OncoTargets and therapy, 13, 2725.

Runhua, M., Qiang, J., Yunqing, S., Wenjun, D., & Chunsheng, W. (2019). FSTL3 induces lipid accumulation and inflammatory response in macrophages and associates with atherosclerosis. Journal of Cardiovascular Pharmacology, 74(6), 566-573.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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