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Mouse Anti-FUBP1 Recombinant Antibody (1E10) (CBMAB-A3220-LY)

The product is antibody recognizes FUBP1. The antibody 1E10 immunoassay techniques such as: WB, ELISA.
See all FUBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
FUBP1 (NP_003893, 27 a.a. ~ 136 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
far upstream element (FUSE) binding protein 1
Introduction
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase. [provided by RefSeq]
Entrez Gene ID
8880
UniProt ID
Q96AE4
Alternative Names
FBP; FUBP
Function
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.
Biological Process
Positive regulation of gene expression Source: UniProtKB
Regulation of gene expression Source: GO_Central
Cellular Location
Nucleus
PTM
Ubiquitinated. This targets the protein for proteasome-mediated degradation.

Yin, H., Gao, T., Xie, J., Huang, Z., Zhang, X., Yang, F., ... & Yang, X. (2021). FUBP1 promotes colorectal cancer stemness and metastasis via DVL1‐mediated activation of Wnt/β‐catenin signaling. Molecular Oncology, 15(12), 3490-3512.

Wang, X., Xing, L., Yang, R., Chen, H., Wang, M., Jiang, R., ... & Chen, J. (2021). The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC. Molecular Cancer, 20(1), 1-21.

Qian, X., Yang, J., Qiu, Q., Li, X., Jiang, C., Li, J., ... & Lu, Y. (2021). LCAT3, a novel m6A-regulated long non-coding RNA, plays an oncogenic role in lung cancer via binding with FUBP1 to activate c-MYC. Journal of hematology & oncology, 14, 1-19.

Han, T., Wu, Y., Hu, X., Chen, Y., Jia, W., He, Q., ... & Wan, X. (2020). NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis. Cell Death & Disease, 11(6), 473.

Kang, M., Kim, H. J., Kim, T. J., Byun, J. S., Lee, J. H., Lee, D. H., ... & Kim, D. Y. (2020). Multiple functions of Fubp1 in cell cycle progression and cell survival. Cells, 9(6), 1347.

Debaize, L., & Troadec, M. B. (2019). The master regulator FUBP1: its emerging role in normal cell function and malignant development. Cellular and Molecular Life Sciences, 76, 259-281.

Hoang, V. T., Verma, D., Godavarthy, P. S., Llavona, P., Steiner, M., Gerlach, K., ... & Krause, D. S. (2019). The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. Leukemia, 33(7), 1700-1712.

Elman, J. S., Ni, T. K., Mengwasser, K. E., Jin, D., Wronski, A., Elledge, S. J., & Kuperwasser, C. (2019). Identification of FUBP1 as a long tail cancer driver and widespread regulator of tumor suppressor and oncogene alternative splicing. Cell reports, 28(13), 3435-3449.

Jiang, P., Huang, M., Qi, W., Wang, F., Yang, T., Gao, T., ... & Yang, X. (2019). FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma. Journal of Experimental & Clinical Cancer Research, 38(1), 1-19.

Debaize, L., Jakobczyk, H., Avner, S., Gaudichon, J., Rio, A. G., Sérandour, A. A., ... & Troadec, M. B. (2018). Interplay between transcription regulators RUNX1 and FUBP1 activates an enhancer of the oncogene c-KIT and amplifies cell proliferation. Nucleic Acids Research, 46(21), 11214-11228.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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