Mouse Anti-FUT1 Recombinant Antibody (CBXF-2523) (CBMAB-F1905-CQ)

Name: Mouse Anti-FUT1 Recombinant Antibody (CBXF-2523)
SKU: CBMAB-F1905-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXF-2523

Application

IHC-P, IHC

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Fucosyltransferase 1 (H Blood Group)

Introduction

This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group.

Entrez Gene ID

2523

UniProt ID

P19526

Alternative Names

Fucosyltransferase 1 (H Blood Group); GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 1; Galactoside 2-Alpha-L-Fucosyltransferase; Blood Group H Alpha 2-Fucosyltransferase; Alpha(1,2)FT 1; HSC; H; Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, Bombay Phenotype Included); Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase);

Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655).

H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178).

Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Fucosylation Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Olfactory bulb development Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of sprouting angiogenesis Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of endothelial cell proliferation Source: UniProtKB

Cellular Location

Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.

Topology

Cytoplasmic: 1-8
Helical: 9-25
Lumenal: 26-365

Rattanapan, Y., Charong, N., Narkpetch, S., & Chareonsirisuthigul, T. (2022). Genotyping of the rare Para-Bombay blood group in southern Thailand. Hematology, Transfusion and Cell Therapy.

Lei, H., Shen, Y., Wang, Y., Su, N., Wang, X., & Cai, X. (2021). A Para-Bombay Blood Group Case Associated with a Novel FUT1 Mutation c. 361G> A. Transfusion Medicine and Hemotherapy, 48(4), 254-258.

Fan, R., Han, X., Gong, Y., He, L., Xue, Z., Yang, Y., ... & Zhang, J. (2021). Alterations of fucosyltransferase genes and fucosylated glycans in gastric epithelial cells infected with Helicobacter pylori. Pathogens, 10(2), 168.

Matzhold, E. M., Wagner, T., Drexler, C., Schönbacher, M., & Körmöczi, G. F. (2020). Aberrant ABO B phenotype with irregular anti-B caused by a para-Bombay FUT1 mutation. Transfusion Medicine and Hemotherapy, 47(1), 94-97.

Lai, T. Y., Chen, I. J., Lin, R. J., Liao, G. S., Yeo, H. L., Ho, C. L., ... & Yu, A. L. (2019). Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. Cell death discovery, 5(1), 74.

Scharberg, E. A., Olsen, C., & Bugert, P. (2019). An update on the H blood group system. Immunohematology, 35(2), 67-68.

Colston, J. M., Francois, R., Pisanic, N., Peñataro Yori, P., McCormick, B. J., Olortegui, M. P., ... & Kosek, M. N. (2019). Effects of child and maternal histo-blood group antigen status on symptomatic and asymptomatic enteric infections in early childhood. The Journal of infectious diseases, 220(1), 151-162.

Lin, J., Chen, R., Zhu, S., Qiu, X., Huang, Y., & Wang, X. (2019). Sequence analysis of α-(1, 2)-fucosyltransferase gene in nine Chinese individuals with Para-Bombay phenotype. Gene, 685, 21-23.

Chen, J., Su, Z., Zhang, C., Li, F., Hwu, P., Wang, Z., ... & Zhou, D. (2019). Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice. bioRxiv, 615070.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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