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Mouse Anti-FUT1 Recombinant Antibody (CBXF-2523) (CBMAB-F1905-CQ)

This product is a mouse antibody that recognizes FUT1. The antibody CBXF-2523 can be used for immunoassay techniques such as: IHC-P, IHC.
See all FUT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2523
Antibody Isotype
IgG1
Application
IHC-P, IHC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Fucosyltransferase 1 (H Blood Group)
Introduction
This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group.
Entrez Gene ID
2523
UniProt ID
P19526
Alternative Names
Fucosyltransferase 1 (H Blood Group); GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 1; Galactoside 2-Alpha-L-Fucosyltransferase; Blood Group H Alpha 2-Fucosyltransferase; Alpha(1,2)FT 1; HSC; H; Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, Bombay Phenotype Included); Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase);
Function
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655).

H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178).

Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).
Biological Process
Carbohydrate metabolic process Source: ProtInc
Fucosylation Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Olfactory bulb development Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of sprouting angiogenesis Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of endothelial cell proliferation Source: UniProtKB
Cellular Location
Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.
Topology
Cytoplasmic: 1-8
Helical: 9-25
Lumenal: 26-365

Rattanapan, Y., Charong, N., Narkpetch, S., & Chareonsirisuthigul, T. (2022). Genotyping of the rare Para-Bombay blood group in southern Thailand. Hematology, Transfusion and Cell Therapy.

Lei, H., Shen, Y., Wang, Y., Su, N., Wang, X., & Cai, X. (2021). A Para-Bombay Blood Group Case Associated with a Novel FUT1 Mutation c. 361G> A. Transfusion Medicine and Hemotherapy, 48(4), 254-258.

Fan, R., Han, X., Gong, Y., He, L., Xue, Z., Yang, Y., ... & Zhang, J. (2021). Alterations of fucosyltransferase genes and fucosylated glycans in gastric epithelial cells infected with Helicobacter pylori. Pathogens, 10(2), 168.

Matzhold, E. M., Wagner, T., Drexler, C., Schönbacher, M., & Körmöczi, G. F. (2020). Aberrant ABO B phenotype with irregular anti-B caused by a para-Bombay FUT1 mutation. Transfusion Medicine and Hemotherapy, 47(1), 94-97.

Lai, T. Y., Chen, I. J., Lin, R. J., Liao, G. S., Yeo, H. L., Ho, C. L., ... & Yu, A. L. (2019). Fucosyltransferase 1 and 2 play pivotal roles in breast cancer cells. Cell death discovery, 5(1), 74.

Scharberg, E. A., Olsen, C., & Bugert, P. (2019). An update on the H blood group system. Immunohematology, 35(2), 67-68.

Colston, J. M., Francois, R., Pisanic, N., Peñataro Yori, P., McCormick, B. J., Olortegui, M. P., ... & Kosek, M. N. (2019). Effects of child and maternal histo-blood group antigen status on symptomatic and asymptomatic enteric infections in early childhood. The Journal of infectious diseases, 220(1), 151-162.

Lin, J., Chen, R., Zhu, S., Qiu, X., Huang, Y., & Wang, X. (2019). Sequence analysis of α-(1, 2)-fucosyltransferase gene in nine Chinese individuals with Para-Bombay phenotype. Gene, 685, 21-23.

Chen, J., Su, Z., Zhang, C., Li, F., Hwu, P., Wang, Z., ... & Zhou, D. (2019). Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice. bioRxiv, 615070.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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