FUT1

This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group.

Full Name

Fucosyltransferase 1 (H Blood Group)

Function

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655).

H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178).

Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity).

Biological Process

Carbohydrate metabolic process Source: ProtInc
Fucosylation Source: UniProtKB
L-fucose catabolic process Source: UniProtKB
Olfactory bulb development Source: UniProtKB
Oligosaccharide biosynthetic process Source: Reactome
Positive regulation of cell-matrix adhesion Source: UniProtKB
Positive regulation of endothelial cell-matrix adhesion via fibronectin Source: UniProtKB
Positive regulation of endothelial cell migration Source: UniProtKB
Positive regulation of sprouting angiogenesis Source: UniProtKB
Protein glycosylation Source: UniProtKB
Regulation of cell adhesion Source: UniProtKB
Regulation of endothelial cell proliferation Source: UniProtKB

Cellular Location

Golgi stack membrane. Membrane-bound form in trans cisternae of Golgi.

Topology

Cytoplasmic: 1-8
Helical: 9-25
Lumenal: 26-365