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Mouse Anti-FXR2 Monoclonal Antibody (A42) (CBMAB-1295-YC)

Provided herein is a mouse monoclonal antibody against Human FXR2. The antibody, clone A42, can be used for immunoassay techniques, such as ELISA, ICC, IF, IP and WB.
See all FXR2 antibodies
Published Data
Fig.1 Western blot analysis of total protein incubated with the four different antibodies. Protein homogenates from human lymphoblastoid cell line, human brain and mouse brain (lanes 1, 2 and 3 respectively) were tested for the presence of FXR2P with AbA42.
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Fig.2 Localization of FMRP and FXR2P in cultured neurons. Cultured mouse hippocampal neurons (9 days in culture) were immunostained for FMRP (A) and FXR2P (B) with the antibodies 1C3 and A42 respectively, using an indirect alkaline phosphatase technique.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
A42
Antibody Isotype
IgG1
Application
ELISA, ICC, IF, IP, WB

Basic Information

Immunogen
His6-FXR2s fusion protein produced in a bacterial pET system
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
FMR1 autosomal homolog 2
Introduction
FXR2 is a RNA binding protein containing two KH domains and one RCG box. FXR2 associates with polyribosomes, predominantly with 60S large ribosomal subunits. FXR2 may have a role in the development of fragile X cognitive disability syndrome.
Entrez Gene ID
9513
UniProt ID
P51116
Alternative Names
FXR2P; FMR1L2
Function
RNA-binding protein.
Biological Process
Negative regulation of translation Source: GO_Central
Positive regulation of protein phosphorylation Source: GO_Central
Positive regulation of response to DNA damage stimulus Source: GO_Central
Positive regulation of translation Source: GO_Central
Regulation of alternative mRNA splicing, via spliceosome Source: GO_Central
Regulation of filopodium assembly Source: GO_Central
Regulation of mRNA stability Source: GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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