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Mouse Anti-FXYD2 (AA 1-65) Recombinant Antibody (CBXF-0973) (CBMAB-F0314-CQ)

This product is a mouse antibody that recognizes FXYD2 (AA 1-65). The antibody CBXF-0973 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all FXYD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-0973
Antibody Isotype
IgG2b
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-65

Target

Full Name
FXYD domain containing ion transport regulator 2
Introduction
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.
Entrez Gene ID
486
UniProt ID
P54710
Alternative Names
FXYD Domain Containing Ion Transport Regulator 2; Na(+)/K(+) ATPase Subunit Gamma; Sodium Pump Gamma Chain; ATP1G1; Sodium/Potassium-Transporting ATPase Subunit Gamma; ATPase, Na+/K+ Transporting, Gamma 1 Polypeptide;
Function
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Biological Process
Positive regulation of P-type sodium:potassium-exchanging transporter activity Source: ARUK-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: GO_Central
Sodium ion export across plasma membrane Source: BHF-UCL
Transmembrane transport Source: BHF-UCL
Cellular Location
Membrane
Involvement in disease
Hypomagnesemia 2 (HOMG2):
A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria.
Topology
Helical: 29-46

Zhang, Z., Tang, Y., Li, L., Yang, W., Xu, Y., Zhou, J., ... & Gong, K. (2022). Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma. Journal of Immunology Research, 2022.

Fabri, L. M., Moraes, C. M., Costa, M. I., Garçon, D. P., Fontes, C. F., Pinto, M. R., ... & Leone, F. A. (2022). Salinity-dependent modulation by protein kinases and the FXYD2 peptide of gill (Na+, K+)-ATPase activity in the freshwater shrimp Macrobrachium amazonicum (Decapoda, Palaemonidae). Biochimica et Biophysica Acta (BBA)-Biomembranes, 1864(10), 183982.

Kaijia, Z. (2022). FXYD2 mRNA expression represents a new independent factor that affects survival of glioma patients and predicts chemosensitivity of patients to temozolomide. Brain Tumor Research and Treatment, 10(Suppl).

Chung, Y. D., Liu, T. H., Liang, Y. L., Lin, C. N., Hsu, K. F., & Lee, G. B. (2021). An integrated microfluidic platform for detection of ovarian clear cell carcinoma mRNA biomarker FXYD2. Lab on a Chip, 21(13), 2625-2632.

Zhou, K., Jiang, T., Liu, Y., Zhao, Z., Huang, L., & Li, G. (2021). FXYD2 mRNA expression represents a new independent factor that affects survival of glioma patients and predicts chemosensitivity of patients to temozolomide. BMC neurology, 21(1), 1-13.

Chung, Y. D., Chuang, Y. J., Lin, C. N., Hsu, K. F., & Lee, G. B. (2021, January). An Integrated Microfluidic Platform to Detect FXYD2 RNA Expression in Ascites for Diagnosis of Ovarian Clear Cell

Leone, F. A., Lucena, M. N., Fabri, L. M., Garçon, D. P., Fontes, C. F., Faleiros, R. O., ... & McNamara, J. C. (2020). Osmotic and ionic regulation, and modulation by protein kinases, FXYD2 peptide and ATP of gill (Na+, K+)-ATPase activity, in the swamp ghost crab Ucides cordatus (Brachyura, Ocypodidae). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 250, 110507.

Leone, F. A., Lucena, M. N., Fabri, L. M., Garçon, D. P., Fontes, C. F., Faleiros, R. O., ... & McNamara, J. C. (2020). Effect of salinity on modulation by ATP, protein kinases and FXYD2 peptide of gill (Na+, K+)-ATPase activity in the swamp ghost crab Ucides cordatus (Brachyura, Ocypodidae). bioRxiv, 2020-04.

Liu, T. H., Lin, C. N., Hsu, K. F., & Lee, G. B. (2019). A microfluidic platform for diagnosis of ovarian clear cell carcinoma via quantification of fxyd2 gene. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 622-623). Chemical and Biological Microsystems Society.

Mayan, H., Farfel, Z., & Karlish, S. J. (2018). Renal Mg handling, FXYD 2 and the central role of the Na, K‐ATP ase. Physiological reports, 6(17), e13843.

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For research use only. Not intended for any clinical use.

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