Mouse Anti-FXYD2 Recombinant Antibody (CBXF-0973) (V2LY-1225-LY342)

Go to compare Compare Online Inquiry
Published Data
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBXF-0973
Application
WB, IP, IF, ELISA, IHC-P
Immunogen
Full length of human FXYD2.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
FXYD domain containing ion transport regulator 2
Entrez Gene ID
UniProt ID
Function
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Biological Process
Positive regulation of P-type sodium:potassium-exchanging transporter activity Source: ARUK-UCL
Potassium ion import across plasma membrane Source: BHF-UCL
Regulation of sodium ion transmembrane transporter activity Source: GO_Central
Sodium ion export across plasma membrane Source: BHF-UCL
Transmembrane transport Source: BHF-UCL
Cellular Location
Membrane
Involvement in disease
Hypomagnesemia 2 (HOMG2):
A disorder due to primary renal wasting of magnesium. Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is lowered renal excretion of calcium resulting in hypocalciuria.
Topology
Helical: 29-46

Zhang, Z., Tang, Y., Li, L., Yang, W., Xu, Y., Zhou, J., ... & Gong, K. (2022). Downregulation of FXYD2 Is Associated with Poor Prognosis and Increased Regulatory T Cell Infiltration in Clear Cell Renal Cell Carcinoma. Journal of Immunology Research, 2022.

Fabri, L. M., Moraes, C. M., Costa, M. I., Garçon, D. P., Fontes, C. F., Pinto, M. R., ... & Leone, F. A. (2022). Salinity-dependent modulation by protein kinases and the FXYD2 peptide of gill (Na+, K+)-ATPase activity in the freshwater shrimp Macrobrachium amazonicum (Decapoda, Palaemonidae). Biochimica et Biophysica Acta (BBA)-Biomembranes, 1864(10), 183982.

Kaijia, Z. (2022). FXYD2 mRNA expression represents a new independent factor that affects survival of glioma patients and predicts chemosensitivity of patients to temozolomide. Brain Tumor Research and Treatment, 10(Suppl).

Chung, Y. D., Liu, T. H., Liang, Y. L., Lin, C. N., Hsu, K. F., & Lee, G. B. (2021). An integrated microfluidic platform for detection of ovarian clear cell carcinoma mRNA biomarker FXYD2. Lab on a Chip, 21(13), 2625-2632.

Zhou, K., Jiang, T., Liu, Y., Zhao, Z., Huang, L., & Li, G. (2021). FXYD2 mRNA expression represents a new independent factor that affects survival of glioma patients and predicts chemosensitivity of patients to temozolomide. BMC neurology, 21(1), 1-13.

Chung, Y. D., Chuang, Y. J., Lin, C. N., Hsu, K. F., & Lee, G. B. (2021, January). An Integrated Microfluidic Platform to Detect FXYD2 RNA Expression in Ascites for Diagnosis of Ovarian Clear Cell

Leone, F. A., Lucena, M. N., Fabri, L. M., Garçon, D. P., Fontes, C. F., Faleiros, R. O., ... & McNamara, J. C. (2020). Osmotic and ionic regulation, and modulation by protein kinases, FXYD2 peptide and ATP of gill (Na+, K+)-ATPase activity, in the swamp ghost crab Ucides cordatus (Brachyura, Ocypodidae). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 250, 110507.

Leone, F. A., Lucena, M. N., Fabri, L. M., Garçon, D. P., Fontes, C. F., Faleiros, R. O., ... & McNamara, J. C. (2020). Effect of salinity on modulation by ATP, protein kinases and FXYD2 peptide of gill (Na+, K+)-ATPase activity in the swamp ghost crab Ucides cordatus (Brachyura, Ocypodidae). bioRxiv, 2020-04.

Liu, T. H., Lin, C. N., Hsu, K. F., & Lee, G. B. (2019). A microfluidic platform for diagnosis of ovarian clear cell carcinoma via quantification of fxyd2 gene. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 622-623). Chemical and Biological Microsystems Society.

Mayan, H., Farfel, Z., & Karlish, S. J. (2018). Renal Mg handling, FXYD 2 and the central role of the Na, K‐ATP ase. Physiological reports, 6(17), e13843.

Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-FXYD2 Recombinant Antibody (CBXF-0973)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry