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Mouse Anti-FZ Recombinant Antibody (1C11) (CBMAB-0066-CN)

This product is a mouse antibody that recognizes FZ of Drosophila. The antibody 1C11 can be used for immunoassay techniques such as: IHC, WB.
See all FZ antibodies

Summary

Host Animal
Mouse
Specificity
Common fruit fly
Clone
1C11
Antibody Isotype
IgG1, κ
Application
IHC, WB

Basic Information

Immunogen
A fusion protein made in E. coli
Specificity
Common fruit fly
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
frizzled
Introduction
Frizzled is the founding member of the Fz family of receptors for Wnt ligands. It is part of Wnt signaling and planar cell polarity pathways. The protein participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult.
Entrez Gene ID
45307
UniProt ID
P18537
Alternative Names
CG17697; CG3646; dFz; Dfz; DFz; Dfz1; DFz1; DFZ1; Dm Fz1; Dmel\CG17697; frz; Frz; Fz; FZ; fz1; Fz1; fz[[1]]
Function
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.
Biological Process
Asymmetric cell division Source: FlyBase
Axon extension Source: FlyBase
Border follicle cell migration Source: FlyBase
Canonical Wnt signaling pathway Source: FlyBase
Cardioblast cell fate specification Source: FlyBase
Chitin-based larval cuticle pattern formation Source: FlyBase
Compound eye morphogenesis Source: FlyBase
Establishment of cell polarity Source: FlyBase
Establishment of imaginal disc-derived wing hair orientation Source: FlyBase
Establishment of ommatidial planar polarity Source: FlyBase
Establishment of planar polarity Source: FlyBase
Establishment or maintenance of cell polarity Source: UniProtKB
Germ-line stem-cell niche homeostasis Source: FlyBase
G protein-coupled receptor signaling pathway Source: FlyBase
Homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
Imaginal disc-derived wing hair organization Source: FlyBase
Imaginal disc-derived wing hair site selection Source: FlyBase
Imaginal disc-derived wing margin morphogenesis Source: FlyBase
Midgut development Source: FlyBase
Morphogenesis of a polarized epithelium Source: FlyBase
Neuron fate specification Source: FlyBase
Ommatidial rotation Source: FlyBase
Positive regulation of axon extension Source: FlyBase
Positive regulation of axon guidance Source: FlyBase
R3/R4 cell differentiation Source: FlyBase
R3/R4 cell fate commitment Source: FlyBase
Regulation of actin filament bundle assembly Source: FlyBase
Regulation of hemocyte proliferation Source: FlyBase
Regulation of tube length, open tracheal system Source: FlyBase
Salivary gland morphogenesis Source: FlyBase
Segment polarity determination Source: FlyBase
Sensory organ precursor cell fate determination Source: FlyBase
Cellular Location
Cell membrane
Topology
Extracellular: 19-247
Helical: 248-270
Cytoplasmic: 271-280
Helical: 281-303
Extracellular: 304-343
Helical: 344-364
Cytoplasmic: 365-380
Helical: 381-401
Extracellular: 402-421
Helical: 422-439
Cytoplasmic: 440-471
Helical: 472-492
Extracellular: 493-529
Helical: 530-553
Cytoplasmic: 554-581
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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