FZ

Frizzled is the founding member of the Fz family of receptors for Wnt ligands. It is part of Wnt signaling and planar cell polarity pathways. The protein participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult.

Full Name

frizzled

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.

Biological Process

Asymmetric cell division Source: FlyBase
Axon extension Source: FlyBase
Border follicle cell migration Source: FlyBase
Canonical Wnt signaling pathway Source: FlyBase
Cardioblast cell fate specification Source: FlyBase
Chitin-based larval cuticle pattern formation Source: FlyBase
Compound eye morphogenesis Source: FlyBase
Establishment of cell polarity Source: FlyBase
Establishment of imaginal disc-derived wing hair orientation Source: FlyBase
Establishment of ommatidial planar polarity Source: FlyBase
Establishment of planar polarity Source: FlyBase
Establishment or maintenance of cell polarity Source: UniProtKB
Germ-line stem-cell niche homeostasis Source: FlyBase
G protein-coupled receptor signaling pathway Source: FlyBase
Homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
Imaginal disc-derived wing hair organization Source: FlyBase
Imaginal disc-derived wing hair site selection Source: FlyBase
Imaginal disc-derived wing margin morphogenesis Source: FlyBase
Midgut development Source: FlyBase
Morphogenesis of a polarized epithelium Source: FlyBase
Neuron fate specification Source: FlyBase
Ommatidial rotation Source: FlyBase
Positive regulation of axon extension Source: FlyBase
Positive regulation of axon guidance Source: FlyBase
R3/R4 cell differentiation Source: FlyBase
R3/R4 cell fate commitment Source: FlyBase
Regulation of actin filament bundle assembly Source: FlyBase
Regulation of hemocyte proliferation Source: FlyBase
Regulation of tube length, open tracheal system Source: FlyBase
Salivary gland morphogenesis Source: FlyBase
Segment polarity determination Source: FlyBase
Sensory organ precursor cell fate determination Source: FlyBase

Cellular Location

Cell membrane

Topology

Extracellular: 19-247
Helical: 248-270
Cytoplasmic: 271-280
Helical: 281-303
Extracellular: 304-343
Helical: 344-364
Cytoplasmic: 365-380
Helical: 381-401
Extracellular: 402-421
Helical: 422-439
Cytoplasmic: 440-471
Helical: 472-492
Extracellular: 493-529
Helical: 530-553
Cytoplasmic: 554-581