Mouse Anti-FZ Recombinant Antibody (CBXF-1816) (CBMAB-F3351-CQ)

frizzled

CG17697; CG3646; DFZ1; DFz; DFz1; Dfz; Dfz1; Dm Fz1; Dmel\CG17697; FZ; Frizzled; Frz; Fz; Fz1; dFz; frz; fz1; fz[[1]]

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.

Asymmetric cell division Source: FlyBase
Axon extension Source: FlyBase
Border follicle cell migration Source: FlyBase
Canonical Wnt signaling pathway Source: FlyBase
Cardioblast cell fate specification Source: FlyBase
Chitin-based larval cuticle pattern formation Source: FlyBase
Compound eye morphogenesis Source: FlyBase
Establishment of cell polarity Source: FlyBase
Establishment of imaginal disc-derived wing hair orientation Source: FlyBase
Establishment of ommatidial planar polarity Source: FlyBase
Establishment of planar polarity Source: FlyBase
Establishment or maintenance of cell polarity Source: UniProtKB
Germ-line stem-cell niche homeostasis Source: FlyBase
G protein-coupled receptor signaling pathway Source: FlyBase
Homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
Imaginal disc-derived wing hair organization Source: FlyBase
Imaginal disc-derived wing hair site selection Source: FlyBase
Imaginal disc-derived wing margin morphogenesis Source: FlyBase
Midgut development Source: FlyBase
Morphogenesis of a polarized epithelium Source: FlyBase
Neuron fate specification Source: FlyBase
Ommatidial rotation Source: FlyBase
Positive regulation of axon extension Source: FlyBase
Positive regulation of axon guidance Source: FlyBase
R3/R4 cell differentiation Source: FlyBase
R3/R4 cell fate commitment Source: FlyBase
Regulation of actin filament bundle assembly Source: FlyBase
Regulation of hemocyte proliferation Source: FlyBase
Regulation of tube length, open tracheal system Source: FlyBase
Salivary gland morphogenesis Source: FlyBase
Segment polarity determination Source: FlyBase
Sensory organ precursor cell fate determination Source: FlyBase

Cell membrane

Extracellular: 19-247
Helical: 248-270
Cytoplasmic: 271-280
Helical: 281-303
Extracellular: 304-343
Helical: 344-364
Cytoplasmic: 365-380
Helical: 381-401
Extracellular: 402-421
Helical: 422-439
Cytoplasmic: 440-471
Helical: 472-492
Extracellular: 493-529
Helical: 530-553
Cytoplasmic: 554-581