Rat Anti-FZD1 (Extracellular domain) Recombinant Antibody (CBXF-0981) (CBMAB-F2508-CQ)

Name: Rat Anti-FZD1 (Extracellular domain) Recombinant Antibody (CBXF-0981)
SKU: CBMAB-F2508-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXF-0981

Application

ELISA, WB

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2, 5% trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

Extracellular domain

More Infomation

Target

Full Name

Frizzled Class Receptor 1

Introduction

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.

Entrez Gene ID

14362

UniProt ID

O70421

Alternative Names

Frizzled Class Receptor 1; Frizzled 1, Seven Transmembrane Spanning Receptor; Frizzled, Drosophila, Homolog Of, 1; Frizzled Family Receptor 1; Wnt Receptor; Fz-1; FzE1;

Function

Receptor for Wnt proteins (PubMed:10557084).

Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).

Contradictory results showing activation by WNT7B have been described for mouse (By similarity).

Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084).

The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084).

A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.

Biological Process

Autocrine signaling Source: BHF-UCL
Canonical Wnt signaling pathway Source: UniProtKB
Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
Canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Neuron differentiation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Presynapse assembly Source: ParkinsonsUK-UCL
Response to drug Source: BHF-UCL
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 73-322
Helical: 323-343
Cytoplasmic: 344-354
Helical: 355-375
Extracellular: 376-402
Helical: 403-423
Cytoplasmic: 424-445
Helical: 446-466
Extracellular: 467-489
Helical: 490-510
Cytoplasmic: 511-536
Helical: 537-557
Extracellular: 558-601
Helical: 602-622
Cytoplasmic: 623-647

PTM

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Jia, F., Zhang, L., Jiang, Z., Tan, G., & Wang, Z. (2023). FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report. BMC Medical Genomics, 16(1), 21.

Liu, X., Low, S. K., Atkins, J. R., Wu, J. Q., Reay, W. R., Cairns, H. M., ... & Cairns, M. J. (2020). Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort. Australian & New Zealand Journal of Psychiatry, 54(9), 902-908.

Peng, Q., Wang, L., Zhao, D., Lv, Y., Wang, H., Chen, G., ... & Xu, W. (2019). Overexpression of FZD1 is associated with a good prognosis and resistance of sunitinib in clear cell renal cell carcinoma. Journal of Cancer, 10(5), 1237.

Wang, Y. H., Imai, Y., Shiseki, M., Tanaka, J., & Motoji, T. (2018). Knockdown of the Wnt receptor Frizzled-1 (FZD1) reduces MDR1/P-glycoprotein expression in multidrug resistant leukemic cells and inhibits leukemic cell proliferation. Leukemia research, 67, 99-108.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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