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Rat Anti-FZD1 Recombinant Antibody (CBXF-2187) (CBMAB-F1886-CQ)

This product is a rat antibody that recognizes FZD1. The antibody CBXF-2187 can be used for immunoassay techniques such as: WB.
See all FZD1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXF-2187
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Mouse recombinant protein Frizzled 1
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Frizzled Class Receptor 1
Introduction
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.
Entrez Gene ID
14362
UniProt ID
O70421
Alternative Names
Frizzled Class Receptor 1; Frizzled 1, Seven Transmembrane Spanning Receptor; Frizzled, Drosophila, Homolog Of, 1; Frizzled Family Receptor 1; Wnt Receptor; Fz-1; FzE1;
Function
Receptor for Wnt proteins (PubMed:10557084).

Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).

Contradictory results showing activation by WNT7B have been described for mouse (By similarity).

Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084).

The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084).

A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Biological Process
Autocrine signaling Source: BHF-UCL
Canonical Wnt signaling pathway Source: UniProtKB
Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
Canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Neuron differentiation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Presynapse assembly Source: ParkinsonsUK-UCL
Response to drug Source: BHF-UCL
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 73-322
Helical: 323-343
Cytoplasmic: 344-354
Helical: 355-375
Extracellular: 376-402
Helical: 403-423
Cytoplasmic: 424-445
Helical: 446-466
Extracellular: 467-489
Helical: 490-510
Cytoplasmic: 511-536
Helical: 537-557
Extracellular: 558-601
Helical: 602-622
Cytoplasmic: 623-647
PTM
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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