FZD1
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Full Name
Frizzled Class Receptor 1
Function
Receptor for Wnt proteins (PubMed:10557084).
Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).
Contradictory results showing activation by WNT7B have been described for mouse (By similarity).
Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084).
The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084).
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).
Contradictory results showing activation by WNT7B have been described for mouse (By similarity).
Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084).
The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084).
A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Biological Process
Autocrine signaling Source: BHF-UCL
Canonical Wnt signaling pathway Source: UniProtKB
Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
Canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Neuron differentiation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Presynapse assembly Source: ParkinsonsUK-UCL
Response to drug Source: BHF-UCL
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Canonical Wnt signaling pathway Source: UniProtKB
Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
Canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Neuron differentiation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Presynapse assembly Source: ParkinsonsUK-UCL
Response to drug Source: BHF-UCL
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 73-322
Helical: 323-343
Cytoplasmic: 344-354
Helical: 355-375
Extracellular: 376-402
Helical: 403-423
Cytoplasmic: 424-445
Helical: 446-466
Extracellular: 467-489
Helical: 490-510
Cytoplasmic: 511-536
Helical: 537-557
Extracellular: 558-601
Helical: 602-622
Cytoplasmic: 623-647
Helical: 323-343
Cytoplasmic: 344-354
Helical: 355-375
Extracellular: 376-402
Helical: 403-423
Cytoplasmic: 424-445
Helical: 446-466
Extracellular: 467-489
Helical: 490-510
Cytoplasmic: 511-536
Helical: 537-557
Extracellular: 558-601
Helical: 602-622
Cytoplasmic: 623-647
PTM
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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Anti-FZD1 antibodies
+ Filters
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CompareTarget: FZD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1251
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-1693
Application*: WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXF-3258
Application*: F, IC, WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-3257
Application*: E, WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXF-3256
Application*: E, F, WB
Target: FZD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1898
Application*: E
Target: FZD1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-2468
Application*: WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-0982
Application*: F, IC, WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-0981
Application*: E, WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-0980
Application*: E, F, WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-2187
Application*: WB
Target: FZD1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1288
Application*: F
Target: FZD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1898
Application*: E
Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXF-2468
Application*: WB
Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXF-0982
Application*: WB, F
Target: FZD1
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Mouse, Rat, Dog, Cattle, Pig, Avian
Clone: CBXF-0981
Application*: WB, IP, IF, E
Target: FZD1
Host: Human
Antibody Isotype: IgG2, λ
Specificity: Human
Clone: CBXF-0980
Application*: F
Target: FZD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2187
Application*: F
Target: FZD1
Host: Human
Antibody Isotype: IgG2, λ
Specificity: Human
Clone: CBXF-1288
Application*: E
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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