FZD1

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]
Full Name
Frizzled Class Receptor 1
Function
Receptor for Wnt proteins (PubMed:10557084).

Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084).

Contradictory results showing activation by WNT7B have been described for mouse (By similarity).

Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084).

The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084).

A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).

(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Biological Process
Autocrine signaling Source: BHF-UCL
Canonical Wnt signaling pathway Source: UniProtKB
Canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation Source: BHF-UCL
Canonical Wnt signaling pathway involved in osteoblast differentiation Source: BHF-UCL
Cell-cell signaling Source: BHF-UCL
Neuron differentiation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of neuron projection development Source: ARUK-UCL
Positive regulation of transcription, DNA-templated Source: BHF-UCL
Presynapse assembly Source: ParkinsonsUK-UCL
Response to drug Source: BHF-UCL
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 73-322
Helical: 323-343
Cytoplasmic: 344-354
Helical: 355-375
Extracellular: 376-402
Helical: 403-423
Cytoplasmic: 424-445
Helical: 446-466
Extracellular: 467-489
Helical: 490-510
Cytoplasmic: 511-536
Helical: 537-557
Extracellular: 558-601
Helical: 602-622
Cytoplasmic: 623-647
PTM
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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Anti-FZD1 antibodies

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Rabbit Anti-FZD1 Recombinant Antibody (EG1251) (CBMAB-EN1514-LY)

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Target: FZD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1251
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-1693) (CBMAB-F4158-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-1693
Application*: WB
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-3258) (CBMAB-F3952-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXF-3258
Application*: F, IC, WB
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-3257) (CBMAB-F3951-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-3257
Application*: E, WB
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-3256) (CBMAB-F3950-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBXF-3256
Application*: E, F, WB
Datasheet SDS

Rabbit Anti-FZD1 Recombinant Antibody (CBXF-1898) (CBMAB-F3428-CQ)

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Target: FZD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXF-1898
Application*: E
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-2468) (CBMAB-F2972-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-2468
Application*: WB
Datasheet SDS

Rat Anti-FZD1 (Extracellular domain) Recombinant Antibody (CBXF-0982) (CBMAB-F2509-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-0982
Application*: F, IC, WB
Datasheet SDS

Rat Anti-FZD1 (Extracellular domain) Recombinant Antibody (CBXF-0981) (CBMAB-F2508-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-0981
Application*: E, WB
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-0980) (CBMAB-F2507-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-0980
Application*: E, F, WB
Datasheet SDS

Rat Anti-FZD1 Recombinant Antibody (CBXF-2187) (CBMAB-F1886-CQ)

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Target: FZD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXF-2187
Application*: WB
Datasheet SDS

Human Anti-FZD1 Recombinant Antibody (CBXF-1288) (CBMAB-F0235-CQ)

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Target: FZD1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1288
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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