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Rat Anti-GABARAPL2 Recombinant Antibody (853746) (CBMAB-G0115-LY)

This product is antibody recognizes GABARAPL2. The antibody 853746 immunoassay techniques such as: WB.
See all GABARAPL2 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse, Rat
Clone
853746
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E.coli-derived recombinant human GATE16, Accession # P60520
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
Trehalose
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
GABA type A receptor associated protein like 2
Entrez Gene ID
Human11345
Mouse93739
Rat64670
UniProt ID
HumanP60520
MouseP60521
RatP60522
Alternative Names
ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2
Function
Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity).

Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity).

It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).

Involved in autophagy (PubMed:20418806, PubMed:23209295).

Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295).

Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295).
Biological Process
Autophagosome assembly Source: GO_Central
Autophagy Source: UniProtKB
Autophagy of mitochondrion Source: GO_Central
Cellular response to nitrogen starvation Source: GO_Central
Intra-Golgi vesicle-mediated transport Source: UniProtKB
Macroautophagy Source: GO_Central
Negative regulation of proteasomal protein catabolic process Source: BHF-UCL
Positive regulation of ATPase activity Source: UniProtKB
Protein localization to endoplasmic reticulum Source: UniProtKB
Protein transport Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus; Autophagosome
PTM
The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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