Rat Anti-GABARAPL2 Recombinant Antibody (853746) (CBMAB-G0115-LY)

Name: Rat Anti-GABARAPL2 Recombinant Antibody (853746)
SKU: CBMAB-G0115-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

853746

Application

Immunogen

E.coli-derived recombinant human GATE16, Accession # P60520

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

lyophilized

Buffer

Trehalose

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

GABA type A receptor associated protein like 2

Entrez Gene ID

Human	11345
Mouse	93739
Rat	64670

UniProt ID

Human	P60520
Mouse	P60521
Rat	P60522

Alternative Names

ATG8; ATG8C; GATE-16; GATE16; GEF-2; GEF2

Function

Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity).

Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity).

It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity).

Involved in autophagy (PubMed:20418806, PubMed:23209295).

Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295).

Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295).

Biological Process

Autophagosome assembly Source: GO_Central
Autophagy Source: UniProtKB
Autophagy of mitochondrion Source: GO_Central
Cellular response to nitrogen starvation Source: GO_Central
Intra-Golgi vesicle-mediated transport Source: UniProtKB
Macroautophagy Source: GO_Central
Negative regulation of proteasomal protein catabolic process Source: BHF-UCL
Positive regulation of ATPase activity Source: UniProtKB
Protein localization to endoplasmic reticulum Source: UniProtKB
Protein transport Source: UniProtKB-KW

Cellular Location

Endoplasmic reticulum membrane; Golgi apparatus; Autophagosome

PTM

The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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