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Mouse Anti-GALNT1 Recombinant Antibody (3C10) (CBMAB-G1852-LY)

This product is antibody recognizes GALNT1. The antibody 3C10 immunoassay techniques such as: ELISA, IF, IHC-P, WB.
See all GALNT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C10
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
Introduction
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2589
UniProt ID
Q10472
Alternative Names
Polypeptide N-Acetylgalactosaminyltransferase 1; Protein-UDP Acetylgalactosaminyltransferase 1; Polypeptide GalNAc Transferase 1; UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 1 (GalNAc-T1); UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 1; Pp-GaNTase 1; EC 2.4.1.41; GALNAC-T1; GalNAc Transferase 1;
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.
Biological Process
O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: UniProtKB
Protein O-linked glycosylation via serine Source: BHF-UCL
Protein O-linked glycosylation via threonine Source: BHF-UCL
Viral protein processing Source: Reactome
Cellular Location
Polypeptide N-acetylgalactosaminyltransferase 1: Golgi stack membrane
Polypeptide N-acetylgalactosaminyltransferase 1 soluble form: Secreted
Topology
Cytoplasmic: 1-8
Helical: 9-28
Lumenal: 29-559
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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