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Mouse Anti-GALNT1 (AA 42-123) Recombinant Antibody (CBFYH-0231) (CBMAB-H1102-FY)

This product is mouse antibody that recognizes GALNT1. The antibody CBFYH-0231 can be used for immunoassay techniques such as: ELISA, WB.
See all GALNT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0231
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa42-123 from human GALNT1 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 42-123

Target

Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
Introduction
This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.
Entrez Gene ID
2589
UniProt ID
Q10472
Alternative Names
Polypeptide N-Acetylgalactosaminyltransferase 1; Protein-UDP Acetylgalactosaminyltransferase 1; Polypeptide GalNAc Transferase 1; UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 1 (GalNAc-T1); UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 1; Pp-GaNTase 1; EC 2.4.1.41; GALNAC-T1; GalNAc Transferase 1
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.
Biological Process
O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: UniProtKB
Protein O-linked glycosylation via serine Source: BHF-UCL
Protein O-linked glycosylation via threonine Source: BHF-UCL
Viral protein processing Source: Reactome
Cellular Location
Polypeptide N-acetylgalactosaminyltransferase 1: Golgi stack membrane
Polypeptide N-acetylgalactosaminyltransferase 1 soluble form: Secreted
Topology
Cytoplasmic: 1-8
Helical: 9-28
Lumenal: 29-559
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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