Mouse Anti-GALNT1 (AA 42-123) Recombinant Antibody (CBFYH-0231) (CBMAB-H1102-FY)

Name: Mouse Anti-GALNT1 (AA 42-123) Recombinant Antibody (CBFYH-0231)
SKU: CBMAB-H1102-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0231

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa42-123 from human GALNT1 with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 42-123

More Infomation

Target

Full Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)

Introduction

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.

Entrez Gene ID

2589

UniProt ID

Q10472

Alternative Names

Polypeptide N-Acetylgalactosaminyltransferase 1; Protein-UDP Acetylgalactosaminyltransferase 1; Polypeptide GalNAc Transferase 1; UDP-N-Acetyl-Alpha-D-Galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 1 (GalNAc-T1); UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferase 1; Pp-GaNTase 1; EC 2.4.1.41; GALNAC-T1; GalNAc Transferase 1

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.

Biological Process

O-glycan processing Source: Reactome
Protein O-linked glycosylation Source: UniProtKB
Protein O-linked glycosylation via serine Source: BHF-UCL
Protein O-linked glycosylation via threonine Source: BHF-UCL
Viral protein processing Source: Reactome

Cellular Location

Polypeptide N-acetylgalactosaminyltransferase 1: Golgi stack membrane
Polypeptide N-acetylgalactosaminyltransferase 1 soluble form: Secreted

Topology

Cytoplasmic: 1-8
Helical: 9-28
Lumenal: 29-559

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-GALNT1 Recombinant Antibody (3C10) (CAT#: CBMAB-G1852-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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