Mouse Anti-GAMT Recombinant Antibody (CBLG1-3137) (CBMAB-G1881-LY)

Name: Mouse Anti-GAMT Recombinant Antibody (CBLG1-3137)
SKU: CBMAB-G1881-LY
Rating: 5 (1 reviews)

See all GAMT antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-3137

Application

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Guanidinoacetate N-Methyltransferase

Introduction

The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. [provided by RefSeq, Feb 2012]

Entrez Gene ID

2593

UniProt ID

Q14353

Alternative Names

Guanidinoacetate N-Methyltransferase; EC 2.1.1.2; Epididymis Secretory Protein Li 20; HEL-S-20; TP53I2; CCDS2; PIG2;

Function

Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor (PubMed:26003046, PubMed:24415674, PubMed:26319512).

Important in nervous system development (PubMed:24415674).

Biological Process

Animal organ morphogenesis Source: Ensembl
Creatine biosynthetic process Source: UniProtKB
Creatine metabolic process Source: Reactome
Methylation Source: UniProtKB-KW
Muscle contraction Source: ProtInc
Regulation of multicellular organism growth Source: Ensembl
Spermatogenesis Source: Ensembl

Cellular Location

Cytosol; Nucleus; Cytoplasm

Involvement in disease

Cerebral creatine deficiency syndrome 2 (CCDS2):
An autosomal recessive disorder characterized by developmental delay and regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures, movement disturbances, severe depletion of creatine and phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-GAMT Recombinant Antibody (CBLG1-3137)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-GAMT Recombinant Antibody (1E7B11) (CAT#: CBMAB-AP2451LY)

Mouse Anti-GAMT Recombinant Antibody (3H4) (CAT#: CBMAB-G1880-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry