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  • Human Anti-GCGR Recombinant Antibody (
    9G1)

Human Anti-GCGR Recombinant Antibody (
9G1) (V2LY-0725-LY719)

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Tested Data
Human Anti-GCGR Recombinant Antibody (9G1) (V2LY-0725-LY719) in ELISA
Human Anti-GCGR Recombinant Antibody (9G1) (V2LY-0725-LY719) in ELISA
The Binding Activity of Human GCGR with Anti-GCGR recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GCGR at 2 μg/mL can bind Anti-GCGR recombinant antibody, the EC50 is 14.57-32.56 ng/mL.
Human Anti-GCGR Recombinant Antibody (9G1) (V2LY-0725-LY719) in ELISA
Human Anti-GCGR Recombinant Antibody (9G1) (V2LY-0725-LY719) in ELISA
The Binding Activity of Human GCGR with Anti-GCGR recombinant antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GCGR at 2 μg/mL can bind Anti-GCGR recombinant antibody, the EC50 is 104.1-179.5 ng/mL.
Datasheet
SDS
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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Human
Clone
9G1
Application
ELISA
Immunogen
Recombinant Human GCGR protein.
Host Species
Human
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
glucagon receptor
Entrez Gene ID
2642
UniProt ID
P47871
Function
G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: UniProtKB
Cell surface receptor signaling pathway Source: InterPro
Cellular response to glucagon stimulus Source: UniProtKB
Cellular response to starvation Source: ARUK-UCL
Exocytosis Source: Ensembl
Generation of precursor metabolites and energy Source: ProtInc
Glucose homeostasis Source: UniProtKB
Hormone-mediated signaling pathway Source: Ensembl
Positive regulation of gene expression Source: ARUK-UCL
Regulation of blood pressure Source: ProtInc
Regulation of glycogen metabolic process Source: UniProtKB
Response to nutrient Source: ProtInc
Response to starvation Source: UniProtKB
Cellular Location
Cell membrane. Is rapidly internalized after ligand-binding.
Topology
Extracellular: 26-136
Helical: 137-161
Cytoplasmic: 162-173
Helical: 174-198
Extracellular: 199-225
Helical: 226-249
Cytoplasmic: 250-263
Helical: 264-285
Extracellular: 286-303
Helical: 304-326
Cytoplasmic: 327-350
Helical: 351-369
Extracellular: 370-381
Helical: 382-402
Cytoplasmic: 403-477
PTM
Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rabbit Anti-GCGR Recombinant Antibody (EG1332) (CAT#: CBMAB-EN1610-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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