Mouse Anti-GCLM Recombinant Antibody (CBLG1-808) (CBMAB-G2648-LY)

Name: Mouse Anti-GCLM Recombinant Antibody (CBLG1-808)
SKU: CBMAB-G2648-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBLG1-808

Application

Immunogen

Glutamate Cysteine Ligase, Modifier Subunit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% NaN3

Concentration

0.5 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glutamate-Cysteine Ligase Modifier Subunit

Introduction

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Entrez Gene ID

2730

UniProt ID

P48507

Alternative Names

Glutamate-Cysteine Ligase Modifier Subunit; Gamma-Glutamylcysteine Synthetase Regulatory Subunit; Gamma-ECS Regulatory Subunit; GCS Light Chain; GLCLR; Glutamate-Cysteine Ligase (Gamma-Glutamylcysteine Synthetase); Regulatory (30.8kD); Glutamate-Cysteine Ligase Modifier Subunit Delta2 Alternative Splicing;

Function

Aging Source: Ensembl
Apoptotic mitochondrial changes Source: Ensembl
Blood vessel diameter maintenance Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: Ensembl
Cellular response to follicle-stimulating hormone stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Cellular response to thyroxine stimulus Source: Ensembl
Cysteine metabolic process Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glutathione biosynthetic process Source: UniProtKB
Hepatic stellate cell activation Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Positive regulation of glutamate-cysteine ligase activity Source: GO_Central
Regulation of mitochondrial depolarization Source: Ensembl
Response to activity Source: Ensembl
Response to drug Source: UniProtKB
Response to human chorionic gonadotropin Source: Ensembl
Response to nitrosative stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB

Biological Process

Cytosol; Glutamate-cysteine ligase complex

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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