GCLM

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Glutamate-Cysteine Ligase Modifier Subunit

Aging Source: Ensembl
Apoptotic mitochondrial changes Source: Ensembl
Blood vessel diameter maintenance Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: Ensembl
Cellular response to follicle-stimulating hormone stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Cellular response to thyroxine stimulus Source: Ensembl
Cysteine metabolic process Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glutathione biosynthetic process Source: UniProtKB
Hepatic stellate cell activation Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Positive regulation of glutamate-cysteine ligase activity Source: GO_Central
Regulation of mitochondrial depolarization Source: Ensembl
Response to activity Source: Ensembl
Response to drug Source: UniProtKB
Response to human chorionic gonadotropin Source: Ensembl
Response to nitrosative stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB

Cytosol; Glutamate-cysteine ligase complex