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GCLM

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Full Name
Glutamate-Cysteine Ligase Modifier Subunit
Function
Aging Source: Ensembl
Apoptotic mitochondrial changes Source: Ensembl
Blood vessel diameter maintenance Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: Ensembl
Cellular response to follicle-stimulating hormone stimulus Source: Ensembl
Cellular response to glucose stimulus Source: Ensembl
Cellular response to hepatocyte growth factor stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Cellular response to thyroxine stimulus Source: Ensembl
Cysteine metabolic process Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glutathione biosynthetic process Source: UniProtKB
Hepatic stellate cell activation Source: Ensembl
Negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
Negative regulation of neuron apoptotic process Source: Ensembl
Positive regulation of glutamate-cysteine ligase activity Source: GO_Central
Regulation of mitochondrial depolarization Source: Ensembl
Response to activity Source: Ensembl
Response to drug Source: UniProtKB
Response to human chorionic gonadotropin Source: Ensembl
Response to nitrosative stress Source: Ensembl
Response to nutrient Source: Ensembl
Response to oxidative stress Source: UniProtKB
Biological Process
Cytosol; Glutamate-cysteine ligase complex
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Anti-GCLM antibodies

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Mouse Anti-GCLM Recombinant Antibody (CAP1037) (CBMAB-AP2480LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CAP1037
Application*: Dot blot, ELISA, WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (CBLG1-809) (CBMAB-G2649-LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-809
Application*: SE, E, WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (CBLG1-808) (CBMAB-G2648-LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-808
Application*: WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (CBLG1-807) (CBMAB-G2647-LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: CBLG1-807
Application*: WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (2B8) (CBMAB-G2641-LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B8
Application*: E, WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (CBLG1-061) (CBMAB-G0304-LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-061
Application*: E, WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (AT2D12) (CBMAB-G0303-LY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT2D12
Application*: IC/IF, F, E, WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (CBFYH-0294) (CBMAB-H1166-FY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0294
Application*: E, EC, WB
Datasheet SDS

Mouse Anti-GCLM Recombinant Antibody (CBFYH-0293) (CBMAB-H1165-FY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYH-0293
Application*: WB
Datasheet SDS

Mouse Anti-GCLM (AA 1-274) Recombinant Antibody (CBFYH-0292) (CBMAB-H1164-FY)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0292
Application*: WB, E
Datasheet SDS

Mouse Anti-GCLM Antibody (6BA14) (CBMAB-1257CQ)

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Target: GCLM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6BA14
Application*: E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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