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Mouse Anti-GDF10 Recombinant Antibody (1B7D12) (CBMAB-AP2483LY)


See all GDF10 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
1B7D12
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Fusion Protein of GDF10
Specificity
Human, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Growth Differentiation Factor 10
Introduction
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]
Entrez Gene ID
Human2662
Rat79216
UniProt ID
HumanP55107
RatP55108
Alternative Names
Growth Differentiation Factor 10; Bone Morphogenetic Protein 3B; Bone-Inducing Protein; BMP-3b; BMP3B; BIP; Growth/Differentiation Factor 10; GDF-10;
Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Biological Process
Negative regulation of osteoblast differentiation Source: UniProtKB
Osteoblast differentiation Source: InterPro
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
Skeletal system development Source: ProtInc
SMAD protein signal transduction Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: ProtInc
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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