Mouse Anti-GDF10 Recombinant Antibody (1B7D12) (CBMAB-AP2483LY)

Name: Mouse Anti-GDF10 Recombinant Antibody (1B7D12)
SKU: CBMAB-AP2483LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1B7D12

Application

ELISA, WB

Immunogen

Fusion Protein of GDF10

Specificity

Human, Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Growth Differentiation Factor 10

Introduction

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]

Entrez Gene ID

Human	2662
Rat	79216

UniProt ID

Human	P55107
Rat	P55108

Alternative Names

Growth Differentiation Factor 10; Bone Morphogenetic Protein 3B; Bone-Inducing Protein; BMP-3b; BMP3B; BIP; Growth/Differentiation Factor 10; GDF-10;

Function

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Biological Process

Negative regulation of osteoblast differentiation Source: UniProtKB
Osteoblast differentiation Source: InterPro
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
Skeletal system development Source: ProtInc
SMAD protein signal transduction Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: ProtInc

Cellular Location

Secreted

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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