GDF10

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer. [provided by RefSeq, Jul 2016]
Full Name
Growth Differentiation Factor 10
Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Biological Process
Negative regulation of osteoblast differentiation Source: UniProtKB
Osteoblast differentiation Source: InterPro
Positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
Skeletal system development Source: ProtInc
SMAD protein signal transduction Source: GO_Central
Transforming growth factor beta receptor signaling pathway Source: ProtInc
Cellular Location
Secreted
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Anti-GDF10 antibodies

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Mouse Anti-GDF10 Recombinant Antibody (1B7D12) (CBMAB-AP2483LY)

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Target: GDF10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 1B7D12
Application*: ELISA, WB
Datasheet SDS

Human GDF10 ELISA Kit (V2LY-0626-LY5484)

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Target: GDF10
Sensitivity: 0.0032 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Recombinant GDF10 protein, hFc Tag (V2LY-0526-LY7876)

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Target: GDF10
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 367-476
Tag: hFc Tag
Datasheet SDS

Mouse Anti-GDF10 Recombinant Antibody (AP2483) (V2LY-1225-LY971)

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Target: GDF10
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Cattle, Pig
Clone: AP2483
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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