Rabbit Anti-GFPT1 Recombinant Antibody (11C1035D12F4) (CBMAB-G3198-LY)

Name: Rabbit Anti-GFPT1 Recombinant Antibody (11C1035D12F4)
SKU: CBMAB-G3198-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

11C1035D12F4

Application

IP, WB

Immunogen

Synthetic peptide corresponding to the sequence around Gly100 of human GFAT1

Specificity

Human, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol, 100 ug/ml BSA

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glutamine--Fructose-6-Phosphate Transaminase 1

Introduction

This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]

Entrez Gene ID

Human	2673
Rat	297417

UniProt ID

Human	Q06210
Rat	P82808

Alternative Names

Glutamine--Fructose-6-Phosphate Transaminase 1; Glutamine:Fructose-6-Phosphate Amidotransferase 1; D-Fructose-6-Phosphate Amidotransferase 1; Hexosephosphate Aminotransferase 1; EC 2.6.1.16; GFAT 1; GFAT1; GFPT; GFAT; Glucosamine--Fructose-6-Phosphate Aminotransferase [Isomerizing] 1;

Function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.

Biological Process

Circadian regulation of gene expression Source: UniProtKB
Energy reserve metabolic process Source: ProtInc
Fructose 6-phosphate metabolic process Source: GO_Central
Glutamine metabolic process Source: UniProtKB-KW
Protein N-linked glycosylation Source: GO_Central
UDP-N-acetylglucosamine biosynthetic process Source: Reactome
UDP-N-acetylglucosamine metabolic process Source: GO_Central

Cellular Location

Cytosol; Extracellular exosome

Involvement in disease

Myasthenic syndrome, congenital, 12 (CMS12):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS12 is characterized by onset of proximal muscle weakness in the first decade. Individuals with this condition have a recognizable pattern of weakness of shoulder and pelvic girdle muscles, and sparing of ocular or facial muscles. EMG classically shows a decremental response to repeated nerve stimulation, a sign of neuromuscular junction dysfunction. Affected individuals show a favorable response to acetylcholinesterase (AChE) inhibitors.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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