Mouse Anti-GFPT1 Recombinant Antibody (CBT4271) (V2LY-0625-LY452)

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Tested Data
Request for COA
Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBT4271
Application
WB, ICC, FC
Immunogen
Purified recombinant fragment of human GFPT1 (AA: 536-681) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
Glutamine--Fructose-6-Phosphate Transaminase 1
Entrez Gene ID
UniProt ID
Function
Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1.
Biological Process
Circadian regulation of gene expression Source: UniProtKB
Energy reserve metabolic process Source: ProtInc
Fructose 6-phosphate metabolic process Source: GO_Central
Glutamine metabolic process Source: UniProtKB-KW
Protein N-linked glycosylation Source: GO_Central
UDP-N-acetylglucosamine biosynthetic process Source: Reactome
UDP-N-acetylglucosamine metabolic process Source: GO_Central
Cellular Location
Cytosol; Extracellular exosome
Involvement in disease
Myasthenic syndrome, congenital, 12 (CMS12):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS12 is characterized by onset of proximal muscle weakness in the first decade. Individuals with this condition have a recognizable pattern of weakness of shoulder and pelvic girdle muscles, and sparing of ocular or facial muscles. EMG classically shows a decremental response to repeated nerve stimulation, a sign of neuromuscular junction dysfunction. Affected individuals show a favorable response to acetylcholinesterase (AChE) inhibitors.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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