Mouse Anti-GGT5 (AA 510-586) Recombinant Antibody (CBFYH-0341) (CBMAB-H1210-FY)

Name: Mouse Anti-GGT5 (AA 510-586) Recombinant Antibody (CBFYH-0341)
SKU: CBMAB-H1210-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0341

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa510-586 from human GGTLA1 with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgM, k

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 510-586

More Infomation

Target

Full Name

Gamma-Glutamyltransferase 5

Introduction

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

2687

UniProt ID

P36269

Alternative Names

Gamma-Glutamyltransferase 5; Gamma-Glutamyltransferase-Like Activity 1; Gamma-Glutamyl Transpeptidase-Related Enzyme; Gamma-Glutamyltranspeptidase 5; Leukotriene-C4 Hydrolase; GGT-REL; GGTLA1; GGT 5; Gamma-Glutamyl Transpeptidase-Related Protein

Function

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318).

Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318).

May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318).

Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).

Biological Process

Cellular amino acid metabolic process Source: UniProtKB
Fatty acid metabolic process Source: BHF-UCL
Glutathione biosynthetic process Source: UniProtKB-KW
Glutathione catabolic process Source: UniProtKB
Inflammatory response Source: GO_Central
Leukotriene D4 biosynthetic process Source: UniProtKB
Proteolysis Source: UniProtKB
Response to estradiol Source: GO_Central
Response to lipopolysaccharide Source: GO_Central
Response to tumor necrosis factor Source: GO_Central
Spermatogenesis Source: GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-586

PTM

Cleaved by autocatalysis into a large and a small subunit.
Glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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