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Mouse Anti-GGT5 (AA 510-586) Recombinant Antibody (CBFYH-0341) (CBMAB-H1210-FY)

This product is mouse antibody that recognizes GGT5. The antibody CBFYH-0341 can be used for immunoassay techniques such as: ELISA, WB.
See all GGT5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0341
Antibody Isotype
IgM, k
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa510-586 from human GGTLA1 with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgM, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 510-586

Target

Full Name
Gamma-Glutamyltransferase 5
Introduction
This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and light subunit, with the catalytic activity contained within the small subunit. The encoded enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
2687
UniProt ID
P36269
Alternative Names
Gamma-Glutamyltransferase 5; Gamma-Glutamyltransferase-Like Activity 1; Gamma-Glutamyl Transpeptidase-Related Enzyme; Gamma-Glutamyltranspeptidase 5; Leukotriene-C4 Hydrolase; GGT-REL; GGTLA1; GGT 5; Gamma-Glutamyl Transpeptidase-Related Protein
Function
Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318).

Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318).

May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318).

Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).
Biological Process
Cellular amino acid metabolic process Source: UniProtKB
Fatty acid metabolic process Source: BHF-UCL
Glutathione biosynthetic process Source: UniProtKB-KW
Glutathione catabolic process Source: UniProtKB
Inflammatory response Source: GO_Central
Leukotriene D4 biosynthetic process Source: UniProtKB
Proteolysis Source: UniProtKB
Response to estradiol Source: GO_Central
Response to lipopolysaccharide Source: GO_Central
Response to tumor necrosis factor Source: GO_Central
Spermatogenesis Source: GO_Central
Cellular Location
Membrane
Topology
Cytoplasmic: 1-8
Helical: 9-29
Extracellular: 30-586
PTM
Cleaved by autocatalysis into a large and a small subunit.
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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