Mouse Anti-GK Recombinant Antibody (CBFYH-0369) (CBMAB-H1239-FY)

Name: Mouse Anti-GK Recombinant Antibody (CBFYH-0369)
SKU: CBMAB-H1239-FY
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBFYH-0369

Application

ELISA

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

glycerol kinase

Introduction

The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

2710

UniProt ID

P32189

Alternative Names

Glycerol Kinase; ATP:Glycerol 3-Phosphotransferase; Glycerokinase; EC 2.7.1.30; GK1; GKD

Function

Key enzyme in the regulation of glycerol uptake and metabolism.

Biological Process

Glycerol-3-phosphate biosynthetic process Source: BHF-UCL
Glycerol catabolic process Source: UniProtKB-UniPathway
Glycerol metabolic process Source: BHF-UCL
Phosphorylation Source: GO_Central
Triglyceride biosynthetic process Source: Reactome
Triglyceride metabolic process Source: BHF-UCL

Cellular Location

Cytoplasm; Mitochondrion outer membrane. In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.

Involvement in disease

Glycerol kinase deficiency (GKD):
A metabolic disorder manifesting as 3 clinically distinct forms: infantile, juvenile, and adult. The infantile form is the most severe and is associated with severe developmental delay and adrenal insufficiency. Patients with the adult form have no symptoms and are often detected fortuitously. GKD results in hyperglycerolemia, a condition characterized by the accumulation of glycerol in the blood and urine.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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