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Rabbit Anti-GK Recombinant Antibody (EG1323) (CBMAB-EN1599-LY)

The product is antibody recognizes GK. The antibody EG1323 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000.
See all GK antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1323
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human GLPK.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glycerol kinase
Introduction
The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human2710
Mouse14933
Rat79223
UniProt ID
HumanP32189
MouseQ64516
RatQ63060
Alternative Names
GK1; GKD
Function
Key enzyme in the regulation of glycerol uptake and metabolism.
Biological Process
Glycerol-3-phosphate biosynthetic process Source: BHF-UCL
Glycerol catabolic process Source: UniProtKB-UniPathway
Glycerol metabolic process Source: BHF-UCL
Phosphorylation Source: GO_Central
Triglyceride biosynthetic process Source: Reactome
Triglyceride metabolic process Source: BHF-UCL
Cellular Location
Cytoplasm; Mitochondrion outer membrane. In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasm.
Involvement in disease
Glycerol kinase deficiency (GKD):
A metabolic disorder manifesting as 3 clinically distinct forms: infantile, juvenile, and adult. The infantile form is the most severe and is associated with severe developmental delay and adrenal insufficiency. Patients with the adult form have no symptoms and are often detected fortuitously. GKD results in hyperglycerolemia, a condition characterized by the accumulation of glycerol in the blood and urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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