Recombinant Mouse Anti-GLO1 Antibody (CBHb366) (CBMAB-Hb518-LY)

Name: Recombinant Mouse Anti-GLO1 Antibody (CBHb366)
SKU: CBMAB-Hb518-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBHb366

Application

Immunogen

Recombinant Glyoxalase I

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% BSA

Preservative

0.02% sodium azide

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glyoxalase I

Introduction

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

Entrez Gene ID

2739

UniProt ID

Q04760

Alternative Names

Glyoxalase I; S-D-Lactoylglutathione Methylglyoxal Lyase; Glyoxalase Domain Containing 1; Ketone-Aldehyde Mutase; Methylglyoxalase; Aldoketomutase; EC 4.4.1.5; Glx I;

Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Biological Process

Carbohydrate metabolic process Source: ProtInc
Glutathione metabolic process Source: Ensembl
Methylglyoxal metabolic process Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Osteoclast differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: Ensembl

Cellular Location

Cytosol; Extracellular exosome; Nucleoplasm; Plasma membrane; Cytoplasm

PTM

Glutathionylation at Cys-139 inhibits enzyme activity.
Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.
Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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