Mouse Anti-GLRA2 Recombinant Antibody (CBLG1-3184) (V2LY-1225-LY1515)

Name: Mouse Anti-GLRA2 Recombinant Antibody (CBLG1-3184)
SKU: V2LY-1225-LY1515
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-3184

Application

WB, IP, IF, ELISA, IHC-P

Immunogen

Amino acids 371-420 mapping at the C-terminus of human GlyR α2.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
IHC-P	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, gelatin

Preservative

Sodium azide

Concentration

0.2 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Glycine Receptor Alpha 2

Entrez Gene ID

2742

UniProt ID

P23416

Function

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488).

Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677).

Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).

Plays a role in cellular responses to ethanol (PubMed:23895467).

Biological Process

Cellular response to amino acid stimulus Source: UniProtKB
Cellular response to ethanol Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Ion transmembrane transport Source: UniProtKB
Nervous system process Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Response to amino acid Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, glycinergic Source: GO_Central

Cellular Location

Postsynaptic cell membrane; Cell membrane; Synapse; Cell projection

Topology

Extracellular: 28-256
Helical: 257-278
Cytoplasmic: 279-283
Helical: 284-304
Extracellular: 305-315
Helical: 316-336
Cytoplasmic: 337-420
Helical: 421-441
Extracellular: 442-452

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-GLRA2 Recombinant Antibody (CBLG1-3184) (CAT#: CBMAB-G3857-LY)

Related Products

Mouse Anti-GLRA2 Recombinant Antibody (CBLG1-3184) (CAT#: CBMAB-G3857-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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