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Mouse Anti-GLRA2 Recombinant Antibody (CBLG1-3184) (CBMAB-G3857-LY)

This product is antibody recognizes GLRA2. The antibody CBLG1-3184 immunoassay techniques such as: WB.
See all GLRA2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-3184
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glycine Receptor Alpha 2
Introduction
The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Entrez Gene ID
2742
UniProt ID
P23416
Alternative Names
Glycine Receptor Alpha 2; Glycine Receptor; Alpha-2 Polypeptide; Glycine Receptor Alpha 2 Subunit; Glycine Receptor Subunit Alpha-2; GLR;
Function
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488).

Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677).

Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).

Plays a role in cellular responses to ethanol (PubMed:23895467).
Biological Process
Cellular response to amino acid stimulus Source: UniProtKB
Cellular response to ethanol Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Ion transmembrane transport Source: UniProtKB
Nervous system process Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Response to amino acid Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, glycinergic Source: GO_Central
Cellular Location
Postsynaptic cell membrane; Cell membrane; Synapse; Cell projection
Topology
Extracellular: 28-256
Helical: 257-278
Cytoplasmic: 279-283
Helical: 284-304
Extracellular: 305-315
Helical: 316-336
Cytoplasmic: 337-420
Helical: 421-441
Extracellular: 442-452
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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