GLRA2

The glycine receptor consists of two subunits, alpha and beta, and acts as a pentamer. The protein encoded by this gene is an alpha subunit and can bind strychnine. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

Full Name

Glycine Receptor Alpha 2

Function

Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:15302677, PubMed:16144831, PubMed:23895467, PubMed:25445488).

Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677).

Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488).

Plays a role in cellular responses to ethanol (PubMed:23895467).

Biological Process

Cellular response to amino acid stimulus Source: UniProtKB
Cellular response to ethanol Source: UniProtKB
Cellular response to zinc ion Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Chloride transmembrane transport Source: UniProtKB
Ion transmembrane transport Source: UniProtKB
Nervous system process Source: GO_Central
Neuropeptide signaling pathway Source: UniProtKB
Regulation of membrane potential Source: GO_Central
Response to amino acid Source: GO_Central
Signal transduction Source: GO_Central
Synaptic transmission, glycinergic Source: GO_Central

Cellular Location

Postsynaptic cell membrane; Cell membrane; Synapse; Cell projection

Topology

Extracellular: 28-256
Helical: 257-278
Cytoplasmic: 279-283
Helical: 284-304
Extracellular: 305-315
Helical: 316-336
Cytoplasmic: 337-420
Helical: 421-441
Extracellular: 442-452