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Mouse Anti-GORASP2 Recombinant Antibody (1F11) (CBMAB-0582-CN)

This product is a mouse antibody that recognizes GORASP2 of human. The antibody 1F11 can be used for immunoassay techniques such as: ELISA, MA.
See all GORASP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F11
Antibody Isotype
IgG2a
Application
ELISA, MA

Basic Information

Immunogen
Recombinant full length protein of GORASP2
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
golgi reassembly stacking protein 2
Introduction
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. It may regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.
Entrez Gene ID
26003
UniProt ID
Q9H8Y8
Alternative Names
p59; GRS2; GOLPH6; GRASP55
Function
Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075).

May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516).

Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity).

Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262).
Biological Process
Cell differentiation Source: UniProtKB-KW
Establishment of protein localization to plasma membrane Source: UniProtKB
Golgi organization Source: GO_Central
Organelle assembly Source: UniProtKB
Organelle organization Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Spermatogenesis Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane; Golgi apparatus. Detected in the intermediate Golgi, membrane-associated (By similarity). ER stress triggers its relocalization from Golgi to ER membrane (PubMed:27062250, PubMed:28067262).
PTM
Myristoylated (PubMed:11101516). Myristoylation is essential for the Golgi targeting (By similarity).
Palmitoylated.
Phosphorylated in mitotic cells (PubMed:11408587). ER stress-induced phosphorylation at Ser-441 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane (PubMed:21884936, PubMed:27062250).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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