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Mouse Anti-GORASP2 Recombinant Antibody (CL2610) (CBMAB-H1298-FY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CL2610
Application
WB, IHC, IF, IHC-P
Immunogen
Recombinant Protein corresponding to amino acids: SGELLSSLPPTSNAPSDPATTTAKADAASSLTVDVTPPTAKAPTTVEDRVGDSTPVSEKPVSAAVDANASESP
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
golgi reassembly stacking protein 2
Introduction
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
26003
UniProt ID
Q9H8Y8
Alternative Names
Golgi Reassembly Stacking Protein 2; Golgi Reassembly Stacking Protein 2, 55kDa; Golgi Phosphoprotein 6; GRASP55; GOLPH6; GRS2
Function
Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis (PubMed:10487747, PubMed:21515684, PubMed:22523075).

May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (PubMed:11101516).

Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells (By similarity).

Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936, PubMed:27062250, PubMed:28067262).
Biological Process
Cell differentiation Source: UniProtKB-KW
Establishment of protein localization to plasma membrane Source: UniProtKB
Golgi organization Source: GO_Central
Organelle assembly Source: UniProtKB
Organelle organization Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Spermatogenesis Source: UniProtKB-KW
Cellular Location
Endoplasmic reticulum membrane; Golgi apparatus membrane; Golgi apparatus. Detected in the intermediate Golgi, membrane-associated (By similarity). ER stress triggers its relocalization from Golgi to ER membrane (PubMed:27062250, PubMed:28067262).
PTM
Myristoylated (PubMed:11101516). Myristoylation is essential for the Golgi targeting (By similarity).
Palmitoylated.
Phosphorylated in mitotic cells (PubMed:11408587). ER stress-induced phosphorylation at Ser-441 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane (PubMed:21884936, PubMed:27062250).

Ise, M., Kageyama, H., Araki, A., & Itami, M. (2019). Identification of a novel GORASP2-ALK fusion in an ALK-positive large B-cell lymphoma. Leukemia & lymphoma, 60(2), 493-497.

Zhang, X., Wang, L., Ireland, S. C., Ahat, E., Li, J., Bekier, M. E., ... & Wang, Y. (2019). GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion. Autophagy, 15(10), 1787-1800.

Husni, R. E., Shiba-Ishii, A., Nakagawa, T., Dai, T., Kim, Y., Hong, J., ... & Noguchi, M. (2019). DNA hypomethylation-related overexpression of SFN, GORASP2 and ZYG11A is a novel prognostic biomarker for early stage lung adenocarcinoma. Oncotarget, 10(17), 1625.

Zhang, X., & Wang, Y. (2018). The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation. Autophagy, 14(9), 1649-1651.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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