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Mouse Anti-GPC5 (AA 1-572) Recombinant Antibody (CBFYH-0438) (CBMAB-H1311-FY)

This product is mouse antibody that recognizes GPC5. The antibody CBFYH-0438 can be used for immunoassay techniques such as: ELISA, IP.
See all GPC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0438
Antibody Isotype
IgG2a, κ
Application
ELISA, IP

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 Kda
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-572

Target

Full Name
glypican 5
Introduction
GPC5 is expressed in podocytes and that the risk genotype is associated with higher expression.
Entrez Gene ID
2262
UniProt ID
P78333
Alternative Names
Glypican 5; Glypican Proteoglycan 5; Glypican-5; BA93M14.1
Function
Cell surface proteoglycan that bears heparan sulfate.
Biological Process
Cell migration Source: GO_Central
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Regulation of protein localization to membrane Source: GO_Central
Cellular Location
Cell membrane
Secreted glypican-5: Extracellular space

Bosworth, A. P., Contreras, M., Novak, S. W., Sancho, L., Salas, I. H., Manor, U., & Allen, N. J. (2023). Astrocyte glypican 5 regulates synapse maturation and stabilization. bioRxiv, 2023-03.

Takeuchi, M., Takeuchi, K., Takai, T., Yamaguchi, R., Furukawa, T., Akagi, K. I., & Takeuchi, J. K. (2021). Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT. Plos one, 16(2), e0226538.

Schlaepfer Sales, C. B., Guimarães, V. S., Valverde, L. F., Dias, R. B., Freitas, R. D., Siquara da Rocha, L. D. O., ... & Gurgel Rocha, C. A. (2021). Glypican-1,-3,-5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry & Molecular Morphology, 29(5), 345-351.

Yang, X., Chen, Y., Zhou, Y., Wu, C., Li, Q., Wu, J., ... & Ji, M. (2021). GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion. Oncogene, 40(25), 4307-4323.

Takeuchi, M., Takeuchi, K., Monobe, Y., Takai, T., Yamaguchi, R., Takeuchi, J. K., & Akagi, K. I. (2019). Subcellular localization of glypican-5 associates with dynamic cell motility and cell communication of the human mesenchymal stem cell line U3DT. bioRxiv, 863720.

Hong, X., Zhang, Z., Pan, L., Ma, W., Zhai, X., Gu, C., ... & Liu, Z. (2019). MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5. European Journal of Pharmacology, 854, 39-47.

Yuan, Q., Zhang, Y., Li, J., Cao, G., & Yang, W. (2018). High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5. Biochemical and biophysical research communications, 497(1), 73-79.

Sun, Y., Xu, K., He, M., Fan, G., & Lu, H. (2018). Overexpression of glypican 5 (GPC5) inhibits prostate cancer cell proliferation and invasion via suppressing Sp1-mediated EMT and activation of Wnt/β-catenin signaling. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 26(4), 565-572.

Chui, M. H., Have, C., Hoang, L. N., Shaw, P., Lee, C. H., & Clarke, B. A. (2018). Genomic profiling identifies GPC5 amplification in association with sarcomatous transformation in a subset of uterine carcinosarcomas. The Journal of Pathology: Clinical Research, 4(1), 69-78.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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