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Rabbit Anti-GPC5 Recombinant Antibody (EG1352) (CBMAB-EN1630-LY)

The product is antibody recognizes GPC5. The antibody EG1352 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all GPC5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG1352
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from Internal of human GPC5.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glypican 5
Introduction
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.
Entrez Gene ID
Human2262
Mouse103978
Rat306157
UniProt ID
HumanP78333
MouseQ8CAL5
Function
Cell surface proteoglycan that bears heparan sulfate.
Biological Process
Cell migration Source: GO_Central
Positive regulation of canonical Wnt signaling pathway Source: GO_Central
Regulation of protein localization to membrane Source: GO_Central
Cellular Location
Cell membrane
Secreted glypican-5: Extracellular space

Bosworth, A. P., Contreras, M., Novak, S. W., Sancho, L., Salas, I. H., Manor, U., & Allen, N. J. (2023). Astrocyte glypican 5 regulates synapse maturation and stabilization. bioRxiv, 2023-03.

Takeuchi, M., Takeuchi, K., Takai, T., Yamaguchi, R., Furukawa, T., Akagi, K. I., & Takeuchi, J. K. (2021). Subcellular localization of glypican-5 is associated with dynamic motility of the human mesenchymal stem cell line U3DT. Plos one, 16(2), e0226538.

Schlaepfer Sales, C. B., Guimarães, V. S., Valverde, L. F., Dias, R. B., Freitas, R. D., Siquara da Rocha, L. D. O., ... & Gurgel Rocha, C. A. (2021). Glypican-1,-3,-5 (GPC1, GPC3, GPC5) and Hedgehog Pathway Expression in Oral Squamous Cell Carcinoma. Applied Immunohistochemistry & Molecular Morphology, 29(5), 345-351.

Yang, X., Chen, Y., Zhou, Y., Wu, C., Li, Q., Wu, J., ... & Ji, M. (2021). GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion. Oncogene, 40(25), 4307-4323.

Takeuchi, M., Takeuchi, K., Monobe, Y., Takai, T., Yamaguchi, R., Takeuchi, J. K., & Akagi, K. I. (2019). Subcellular localization of glypican-5 associates with dynamic cell motility and cell communication of the human mesenchymal stem cell line U3DT. bioRxiv, 863720.

Hong, X., Zhang, Z., Pan, L., Ma, W., Zhai, X., Gu, C., ... & Liu, Z. (2019). MicroRNA-301b promotes the proliferation and invasion of glioma cells through enhancing activation of Wnt/β-catenin signaling via targeting Glypican-5. European Journal of Pharmacology, 854, 39-47.

Yuan, Q., Zhang, Y., Li, J., Cao, G., & Yang, W. (2018). High expression of microRNA-4295 contributes to cell proliferation and invasion of pancreatic ductal adenocarcinoma by the down-regulation of Glypican-5. Biochemical and biophysical research communications, 497(1), 73-79.

Sun, Y., Xu, K., He, M., Fan, G., & Lu, H. (2018). Overexpression of glypican 5 (GPC5) inhibits prostate cancer cell proliferation and invasion via suppressing Sp1-mediated EMT and activation of Wnt/β-catenin signaling. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, 26(4), 565-572.

Chui, M. H., Have, C., Hoang, L. N., Shaw, P., Lee, C. H., & Clarke, B. A. (2018). Genomic profiling identifies GPC5 amplification in association with sarcomatous transformation in a subset of uterine carcinosarcomas. The Journal of Pathology: Clinical Research, 4(1), 69-78.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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