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Rabbit Anti-GRIK3 Recombinant Antibody (BA0135) (CBMAB-0355CQ)

This product is a rabbit antibody that recognizes GRIK3. The antibody BA0135 can be used for immunoassay techniques such as: WB.
See all GRIK3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0135
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human GRIK3 aa 850 to the C-terminus
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
glutamate receptor, ionotropic, kainate 3
Introduction
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. By somatic cell hybrid analysis, Puranam et al. (1993) mapped the GLUR7 gene to chromosome 1. By fluorescence in situ hybridization, the gene was regionalized to 1p34-p33. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
Entrez Gene ID
Human2899
Mouse14807
Rat298521
UniProt ID
HumanQ13003
MouseB1AS29
RatP42264
Alternative Names
EAA5; GLR7; GLUR7; GluK3; GluR7a
Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate> kainate>> L-glutamate = quisqualate>> AMPA = NMDA.
Biological Process
Glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Modulation of chemical synaptic transmission Source: GO_Central
Negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
Regulation of membrane potential Source: MGI
Synaptic transmission, glutamatergic Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 32-563
Helical: 564-584
Cytoplasmic: 585-636
Helical: 637-657
Extracellular: 658-820
Helical: 821-841
Cytoplasmic: 842-919
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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