Mouse Anti-GRIK3 Recombinant Antibody (CBLG1-1747) (V2LY-0226-LY1202)

Name: Mouse Anti-GRIK3 Recombinant Antibody (CBLG1-1747)
SKU: V2LY-0226-LY1202
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-1747

Application

IHC

Immunogen

Human GRIK3 containing peptide.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

glutamate receptor, ionotropic, kainate 3

Entrez Gene ID

2899

UniProt ID

Q13003

Function

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate> kainate>> L-glutamate = quisqualate>> AMPA = NMDA.

Biological Process

Glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Modulation of chemical synaptic transmission Source: GO_Central
Negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
Regulation of membrane potential Source: MGI
Synaptic transmission, glutamatergic Source: GO_Central

Cellular Location

Cell membrane; Postsynaptic cell membrane

Topology

Extracellular: 32-563
Helical: 564-584
Cytoplasmic: 585-636
Helical: 637-657
Extracellular: 658-820
Helical: 821-841
Cytoplasmic: 842-919

Xiao, B., Kuang, Z., Zhang, W., Hang, J., Chen, L., Lei, T., ... & Li, L. (2019). Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial‐mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling. Molecular Carcinogenesis, 58(7), 1314-1323.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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