GRIK3

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq]

glutamate receptor, ionotropic, kainate 3

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate> kainate>> L-glutamate = quisqualate>> AMPA = NMDA.

Glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Modulation of chemical synaptic transmission Source: GO_Central
Negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
Regulation of membrane potential Source: MGI
Synaptic transmission, glutamatergic Source: GO_Central

Cell membrane; Postsynaptic cell membrane

Extracellular: 32-563
Helical: 564-584
Cytoplasmic: 585-636
Helical: 637-657
Extracellular: 658-820
Helical: 821-841
Cytoplasmic: 842-919