GRIK3

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq]
Full Name
glutamate receptor, ionotropic, kainate 3
Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate> kainate>> L-glutamate = quisqualate>> AMPA = NMDA.
Biological Process
Glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Modulation of chemical synaptic transmission Source: GO_Central
Negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
Regulation of membrane potential Source: MGI
Synaptic transmission, glutamatergic Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 32-563
Helical: 564-584
Cytoplasmic: 585-636
Helical: 637-657
Extracellular: 658-820
Helical: 821-841
Cytoplasmic: 842-919
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Anti-GRIK3 antibodies

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Mouse Anti-GRIK3 Recombinant Antibody (CBLG1-1747) (V2LY-0226-LY1202)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-1747
Application*: IH
Datasheet SDS

Mouse Anti-GRIK3 Recombinant Antibody (G4925) (V2LY-0226-LY1195)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G4925
Application*: E, IF
Datasheet SDS

Mouse Anti-GRIK3 Recombinant Antibody (G4922) (V2LY-0226-LY1194)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: G4922
Application*: E, F, WB
Datasheet SDS

Mouse Anti-GRIK3 Recombinant Antibody (CBT4527) (V2LY-0625-LY813)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4527
Application*: WB, F
Datasheet SDS

Mouse Anti-GRIK3 Recombinant Antibody (CBT3205) (V2LY-0625-LY741)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3205
Application*: IC
Datasheet SDS

Rabbit Anti-GRIK3 Recombinant Antibody (4H1) (CBMAB-G4932-LY)

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Target: GRIK3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 4H1
Application*: F
Datasheet SDS

Mouse Anti-GRIK3 Recombinant Antibody (2Q57) (CBMAB-G4931-LY)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2Q57
Application*: WB, E, F
Datasheet SDS

Mouse Anti-GRIK3 Recombinant Antibody (BA0135) (CBMAB-0355CQ)

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Target: GRIK3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BA0135
Application*: WB, E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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