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Mouse Anti-GRIK3 Recombinant Antibody (CBLG1-1747) (CBMAB-G4934-LY)

This product is antibody recognizes GRIK3. The antibody CBLG1-1747 immunoassay techniques such as: IHC, ICC.
See all GRIK3 antibodies

Summary

Host Animal
Mouse
Specificity
Fish, Hamster, Human, Monkey, Mouse, Rabbit, Rat
Clone
CBLG1-1747
Antibody Isotype
IgG
Application
IHC, ICC

Basic Information

Immunogen
Glutamate
Specificity
Fish, Hamster, Human, Monkey, Mouse, Rabbit, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
glutamate receptor, ionotropic, kainate 3
Introduction
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human2899
Mouse14807
Rat298521
Hamster101835454
Monkey713545
Rabbit100354824
UniProt ID
HumanQ13003
MouseB1AS29
RatP42264
HamsterA0A1U7R2L0
MonkeyF6YBQ8
RabbitG1SP91
Function
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate> kainate>> L-glutamate = quisqualate>> AMPA = NMDA.
Biological Process
Glutamate receptor signaling pathway Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Modulation of chemical synaptic transmission Source: GO_Central
Negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
Regulation of membrane potential Source: MGI
Synaptic transmission, glutamatergic Source: GO_Central
Cellular Location
Cell membrane; Postsynaptic cell membrane
Topology
Extracellular: 32-563
Helical: 564-584
Cytoplasmic: 585-636
Helical: 637-657
Extracellular: 658-820
Helical: 821-841
Cytoplasmic: 842-919
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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