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Mouse Anti-GRPR Recombinant Antibody (1A9) (CBMAB-G5096-LY)

This product is antibody recognizes GRPR. The antibody 1A9 immunoassay techniques such as: ELISA.
See all GRPR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A9
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gastrin-releasing peptide receptor
Introduction
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2925
UniProt ID
P30550
Alternative Names
Gastrin Releasing Peptide Receptor; GRP-Preferring Bombesin Receptor; Bombesin Receptor 2; GRP-R; Gastrin-Releasing Peptide Receptor; BB2R; BB2;
Function
Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761).

Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).
Biological Process
G protein-coupled receptor signaling pathway Source: GO_Central
Learning or memory Source: Ensembl
Motor behavior Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Social behavior Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-38
Helical: 39-62
Cytoplasmic: 63-76
Helical: 77-96
Extracellular: 97-114
Helical: 115-136
Cytoplasmic: 137-152
Helical: 153-174
Extracellular: 175-208
Helical: 209-234
Cytoplasmic: 235-264
Helical: 265-285
Extracellular: 286-298
Helical: 299-325
Cytoplasmic: 326-384

Rurarz, B. P., Bukowczyk, M., Gibka, N., Piastowska-Ciesielska, A. W., Karczmarczyk, U., & Ulański, P. (2023). Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor. International Journal of Molecular Sciences, 24(4), 3455.

Chernov, V., Rybina, A., Zelchan, R., Medvedeva, A., Bragina, O., Lushnikova, N., ... & Orlova, A. (2023). Phase I Trial of [99mTc] Tc-MaSSS-PEG2-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors. Cancers, 15(6), 1631.

Peng, S., Zhan, Y., Zhang, D., Ren, L., Chen, A., Chen, Z. F., & Zhang, H. (2023). Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy. Proceedings of the National Academy of Sciences, 120(6), e2216230120.

Takanami, K., Uta, D., Matsuda, K. I., Kawata, M., Carstens, E., Sakamoto, T., & Sakamoto, H. (2021). Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons. Proceedings of the National Academy of Sciences, 118(31), e2103536118.

Faviana, P., Boldrini, L., Erba, P. A., Di Stefano, I., Manassero, F., Bartoletti, R., ... & Bardi, M. (2021). Gastrin-releasing peptide receptor in low grade prostate cancer: Can it be a better predictor than prostate-specific membrane antigen?. Frontiers in Oncology, 11, 650249.

Tu, Y., Tao, J., Wang, F., Liu, P., Han, Z., Li, Z., ... & Gu, Y. (2020). A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection. Biomaterials science, 8(9), 2682-2693.

Hoppenz, P., Els‐Heindl, S., & Beck‐Sickinger, A. G. (2019). Identification and stabilization of a highly selective gastrin‐releasing peptide receptor agonist. Journal of Peptide Science, 25(12), e3224.

Nock, B. A., Charalambidis, D., Sallegger, W., Waser, B., Mansi, R., Nicolas, G. P., ... & Maina, T. (2018). New gastrin releasing peptide receptor-directed [99mTc] Demobesin 1 mimics: Synthesis and comparative evaluation. Journal of medicinal chemistry, 61(7), 3138-3150.

Baratto, L., Jadvar, H., & Iagaru, A. (2018). Prostate cancer theranostics targeting gastrin-releasing peptide receptors. Molecular imaging and biology, 20, 501-509.

Begum, A. A., Wan, Y., Toth, I., & Moyle, P. M. (2018). Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery. Bioorganic & Medicinal Chemistry, 26(2), 516-526.

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For research use only. Not intended for any clinical use.

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