GRPR

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq]

gastrin-releasing peptide receptor

Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761).

Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).

G protein-coupled receptor signaling pathway Source: GO_Central
Learning or memory Source: Ensembl
Motor behavior Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Social behavior Source: UniProtKB

Cell membrane

Extracellular: 1-38
Helical: 39-62
Cytoplasmic: 63-76
Helical: 77-96
Extracellular: 97-114
Helical: 115-136
Cytoplasmic: 137-152
Helical: 153-174
Extracellular: 175-208
Helical: 209-234
Cytoplasmic: 235-264
Helical: 265-285
Extracellular: 286-298
Helical: 299-325
Cytoplasmic: 326-384