Mouse Anti-GRPR Recombinant Antibody (3A11) (V2LY-0226-LY1457)

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Basic Information

Host Animal
Mouse
Clone
3A11
Application
ELISA, IP, IF, WB
Immunogen
Amino acids 1-50 mapping at the N-terminus of human GRPR.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, gelatin
Preservative
Sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
gastrin-releasing peptide receptor
Entrez Gene ID
UniProt ID
Function
Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761).

Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity).
Biological Process
G protein-coupled receptor signaling pathway Source: GO_Central
Learning or memory Source: Ensembl
Motor behavior Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Social behavior Source: UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 1-38
Helical: 39-62
Cytoplasmic: 63-76
Helical: 77-96
Extracellular: 97-114
Helical: 115-136
Cytoplasmic: 137-152
Helical: 153-174
Extracellular: 175-208
Helical: 209-234
Cytoplasmic: 235-264
Helical: 265-285
Extracellular: 286-298
Helical: 299-325
Cytoplasmic: 326-384

Rurarz, B. P., Bukowczyk, M., Gibka, N., Piastowska-Ciesielska, A. W., Karczmarczyk, U., & Ulański, P. (2023). Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor. International Journal of Molecular Sciences, 24(4), 3455.

Chernov, V., Rybina, A., Zelchan, R., Medvedeva, A., Bragina, O., Lushnikova, N., ... & Orlova, A. (2023). Phase I Trial of [99mTc] Tc-MaSSS-PEG2-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR Expression in Malignant Tumors. Cancers, 15(6), 1631.

Peng, S., Zhan, Y., Zhang, D., Ren, L., Chen, A., Chen, Z. F., & Zhang, H. (2023). Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy. Proceedings of the National Academy of Sciences, 120(6), e2216230120.

Takanami, K., Uta, D., Matsuda, K. I., Kawata, M., Carstens, E., Sakamoto, T., & Sakamoto, H. (2021). Estrogens influence female itch sensitivity via the spinal gastrin-releasing peptide receptor neurons. Proceedings of the National Academy of Sciences, 118(31), e2103536118.

Faviana, P., Boldrini, L., Erba, P. A., Di Stefano, I., Manassero, F., Bartoletti, R., ... & Bardi, M. (2021). Gastrin-releasing peptide receptor in low grade prostate cancer: Can it be a better predictor than prostate-specific membrane antigen?. Frontiers in Oncology, 11, 650249.

Tu, Y., Tao, J., Wang, F., Liu, P., Han, Z., Li, Z., ... & Gu, Y. (2020). A novel peptide targeting gastrin releasing peptide receptor for pancreatic neoplasm detection. Biomaterials science, 8(9), 2682-2693.

Hoppenz, P., Els‐Heindl, S., & Beck‐Sickinger, A. G. (2019). Identification and stabilization of a highly selective gastrin‐releasing peptide receptor agonist. Journal of Peptide Science, 25(12), e3224.

Nock, B. A., Charalambidis, D., Sallegger, W., Waser, B., Mansi, R., Nicolas, G. P., ... & Maina, T. (2018). New gastrin releasing peptide receptor-directed [99mTc] Demobesin 1 mimics: Synthesis and comparative evaluation. Journal of medicinal chemistry, 61(7), 3138-3150.

Baratto, L., Jadvar, H., & Iagaru, A. (2018). Prostate cancer theranostics targeting gastrin-releasing peptide receptors. Molecular imaging and biology, 20, 501-509.

Begum, A. A., Wan, Y., Toth, I., & Moyle, P. M. (2018). Bombesin/oligoarginine fusion peptides for gastrin releasing peptide receptor (GRPR) targeted gene delivery. Bioorganic & Medicinal Chemistry, 26(2), 516-526.

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For research use only. Not intended for any clinical use.

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