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Mouse Anti-HABP2 Recombinant Antibody (1H4) (CBMAB-A3722-LY)

The product is antibody recognizes HABP2. The antibody 1H4 immunoassay techniques such as: IP, ELISA.
See all HABP2 antibodies
Published Data
Fig. 1 Immunohistochemical staining of HABP2 in the endometria of a fertile woman.
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Fig. 2 Extracted lungs were homogenized and serum prepared, run on SDS-PAGE and immunoblotted with anti-HABP2.
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Fig. 3 Immunohistochemical fluorescent staining images of control or LPS-treated mouse lungs using either bright field (DIC) imaging with anti-HABP2 antibody.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1H4
Antibody Isotype
IgG2a, κ
Application
IP, ELISA

Basic Information

Immunogen
HABP2 (NP_004123, 105 a.a. ~ 204 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
hyaluronan binding protein 2
Introduction
The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. [provided by RefSeq]
Entrez Gene ID
3026
UniProt ID
Q14520
Alternative Names
FSAP; HABP; HGFAL; PHBP
Function
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080).

May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).
Biological Process
Cell adhesion Source: ProtInc
Proteolysis Source: MGI
Cellular Location
Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Involvement in disease
Thyroid cancer, non-medullary, 5 (NMTC5):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
PTM
Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity).

Luo, H., Huang, Q., Huang, D., Liu, C., Long, X., & Tang, R. (2023). HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke. ACS Chemical Neuroscience.

Cheng, L., Wang, D., Wang, Z., Li, H., Wang, G., Wu, Z., ... & Li, Y. (2022). Proteomic landscape mapping of organ-resolved Behçet's syndrome using in-depth plasma proteomics for identifying HABP2 expression associated with vascular involvement. Arthritis & Rheumatology (Hoboken, NJ).

Jiang, Y., Li, J., Sang, C., Cao, G., & Wang, S. (2020). Diagnostic and prognostic value of HABP2 as a novel biomarker for endometrial cancer. Annals of Translational Medicine, 8(18).

de Randamie, R., Martos-Moreno, G. Á., Lumbreras, C., Chueca, M., Donnay, S., Luque, M., ... & Moreno, J. C. (2018). Frequent and rare HABP2 variants are not associated with increased Susceptibility to familial nonmedullary Thyroid carcinoma in the Spanish population. Hormone Research in Paediatrics, 89(6), 397-407.

Husseini-Akram, F., Haroun, S., Altmäe, S., Skjöldebrand-Sparre, L., Åkerud, H., Poromaa, I. S., ... & Stavreus-Evers, A. (2018). Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage. BMC women's health, 18, 1-6.

Colombo, C., Fugazzola, L., Muzza, M., Proverbio, M. C., & Cirello, V. (2018). Letter regarding the article:“Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of “thyroid-checked” controls” by Kern et al. European Journal of Medical Genetics, 61(2), 104-105.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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