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Mouse Anti-HABP2 (AA 33-330) Recombinant Antibody (CBFYH-0647) (CBMAB-H1529-FY)

This product is mouse antibody that recognizes HABP2. The antibody CBFYH-0647 can be used for immunoassay techniques such as: WB, IHC.
See all HABP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0647
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 33-330 of human HABP2 produced in E.coli
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 33-330

Target

Full Name
hyaluronan binding protein 2
Introduction
This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Entrez Gene ID
3026
UniProt ID
Q14520
Alternative Names
Hyaluronan Binding Protein 2; Hepatocyte Growth Factor Activator-Like Protein; Plasma Hyaluronan Binding Protein; Factor Seven-Activating Protease; Factor VII-Activating Protease; Factor VII Activating Protein; Hyaluronan-Binding Protein 2; HGFAL; FSAP; PHBP
Function
Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (PubMed:8827452, PubMed:10754382, PubMed:11217080).

May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560).
Biological Process
Cell adhesion Source: ProtInc
Proteolysis Source: MGI
Cellular Location
Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
Involvement in disease
Thyroid cancer, non-medullary, 5 (NMTC5):
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
PTM
Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments (By similarity).

Luo, H., Huang, Q., Huang, D., Liu, C., Long, X., & Tang, R. (2023). HABP2 Encapsulated by Peripheral Blood-Derived Exosomes Suppresses Astrocyte Autophagy to Exacerbate Neuroinflammatory Injury in Mice with Ischemic Stroke. ACS Chemical Neuroscience.

Cheng, L., Wang, D., Wang, Z., Li, H., Wang, G., Wu, Z., ... & Li, Y. (2022). Proteomic landscape mapping of organ-resolved Behçet's syndrome using in-depth plasma proteomics for identifying HABP2 expression associated with vascular involvement. Arthritis & Rheumatology (Hoboken, NJ).

Jiang, Y., Li, J., Sang, C., Cao, G., & Wang, S. (2020). Diagnostic and prognostic value of HABP2 as a novel biomarker for endometrial cancer. Annals of Translational Medicine, 8(18).

de Randamie, R., Martos-Moreno, G. Á., Lumbreras, C., Chueca, M., Donnay, S., Luque, M., ... & Moreno, J. C. (2018). Frequent and rare HABP2 variants are not associated with increased Susceptibility to familial nonmedullary Thyroid carcinoma in the Spanish population. Hormone Research in Paediatrics, 89(6), 397-407.

Husseini-Akram, F., Haroun, S., Altmäe, S., Skjöldebrand-Sparre, L., Åkerud, H., Poromaa, I. S., ... & Stavreus-Evers, A. (2018). Hyaluronan–binding protein 2 (HABP2) gene variation in women with recurrent miscarriage. BMC women's health, 18, 1-6.

Colombo, C., Fugazzola, L., Muzza, M., Proverbio, M. C., & Cirello, V. (2018). Letter regarding the article:“Multiple HABP2 variants in familial papillary thyroid carcinoma: Contribution of a group of “thyroid-checked” controls” by Kern et al. European Journal of Medical Genetics, 61(2), 104-105.

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For research use only. Not intended for any clinical use.

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