Mouse Anti-HDAC7 Antibody (1A3) (CBMAB-0444-YC)

Name: Mouse Anti-HDAC7 Antibody (1A3)
SKU: CBMAB-0444-YC
Rating: 5 (1 reviews)

See all HDAC7 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1A3

Application

IP, MA

Immunogen

Recombinant protein

Specificity

Human

Antibody Isotype

IgG2c

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Histone Deacetylase 7

Introduction

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC7 (histone deacetylase 7) has sequence homology to members of the histone deacetylase family and is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT.

Entrez Gene ID

51564

UniProt ID

Q8WUI4

Alternative Names

HD7; HD7A; HDAC7A

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity).

May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758).

In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).

Biological Process

Cell-cell junction assembly Source: Ensembl
Chromatin organization Source: UniProtKB-KW
Negative regulation of interleukin-2 production Source: BHF-UCL
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Negative regulation of osteoblast differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Protein deacetylation Source: UniProtKB
Vasculogenesis Source: Ensembl

Cellular Location

Nucleus; Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

PTM

May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.

Ramnath, D., Das Gupta, K., Wang, Y., Abrol, R., Curson, J. E., Lim, J., ... & Sweet, M. J. (2022). The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111(2), 327-336.

Xu, C., Sun, W., Liu, J., Pu, H., & Li, Y. (2022). MiR-342-3p inhibits LCSC oncogenicity and cell stemness through HDAC7/PTEN axis. Inflammation Research, 1-11.

Guo, K., Ma, Z., Zhang, Y., Han, L., Shao, C., Feng, Y., ... & Yan, X. (2022). HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 91.

Axisa, P. P., Yoshida, T. M., Lucca, L. E., Kasler, H. G., Lincoln, M. R., Pham, G. H., ... & Hafler, D. A. (2022). A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Science Translational Medicine, 14(675), eabl3651.

Ye, J., Zhong, S., Deng, Y., Yao, X., Liu, Q., Wang, J. Z., & Xiao, S. (2022). HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. Molecular Neurobiology, 59(10), 6141-6157.

Ma, Z. Q., Feng, Y. T., Guo, K., Liu, D., Shao, C. J., Pan, M. H., ... & Hu, Y. (2022). Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Military Medical Research, 9(1), 54.

Hsu, A., Duan, Q., McMahon, S., Huang, Y., Wood, S. A., Gray, N. S., ... & Haldar, S. M. (2020). Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. The Journal of clinical investigation, 130(6), 2966-2977.

Wang, R., Zhang, H., Ding, W., Fan, Z., Ji, B., Ding, C., ... & Tang, H. (2020). miR-143 promotes angiogenesis and osteoblast differentiation by targeting HDAC7. Cell Death & Disease, 11(3), 179.

Caslini, C., Hong, S., Ban, Y. J., Chen, X. S., & Ince, T. A. (2019). HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells. Oncogene, 38(39), 6599-6614.

Daneshpajooh, M., Eliasson, L., Bacos, K., & Ling, C. (2018). MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation. Acta diabetologica, 55, 1231-1235.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-HDAC7 Antibody (1A3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

HDAC7 Matched Antibody Pair (535) (CAT#: APMAB-535LY)

HDAC7 Matched Antibody Pair (536) (CAT#: APMAB-536LY)

Related Products

Rabbit Anti-HDAC7 Recombinant Antibody (CBFYH-0889) (CAT#: CBMAB-H1817-FY)

Mouse Anti-HDAC7 Recombinant Antibody (CBFYH-0888) (CAT#: CBMAB-H1816-FY)

HDAC7 Matched Antibody Pair (535) (CAT#: APMAB-535LY)

Mouse Anti-HDAC7 Recombinant Antibody (CBFYH-0885) (CAT#: CBMAB-H0667-FY)

Rabbit Anti-HDAC7 Recombinant Antibody (E7O8V) (CAT#: CBMAB-CP0928-LY)

Mouse Anti-HDAC7 (AA 7-97) Monoclonal Antibody (CBFYH-3042) (CAT#: CBMAB-H1813-FY)

HDAC7 Matched Antibody Pair (536) (CAT#: APMAB-536LY)

Mouse Anti-HDAC7 Recombinant Antibody (9G369) (CAT#: CBMAB-H1812-FY)

Human Recombinant HDAC7, Active protein, GST Tag (CAT#: V2LY-0526-LY4472)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry