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HDAC7 Matched Antibody Pair (535) (APMAB-535LY)

This antibody pair set can be used for detecting and quantifying protein level of human HDAC7.
See all HDAC7 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-HDAC7 polyclonal antibody, 100 ug
Detection Antibody
Anti-HDAC7 Mouse monoclonal, IgG2b antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Alternative Names
Histone Deacetylase 7; Histone Deacetylase 7A; EC 3.5.1.98; HDAC7A; HD7A; HD7;
Entrez Gene ID
UniProt ID

Ramnath, D., Das Gupta, K., Wang, Y., Abrol, R., Curson, J. E., Lim, J., ... & Sweet, M. J. (2022). The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111(2), 327-336.

Xu, C., Sun, W., Liu, J., Pu, H., & Li, Y. (2022). MiR-342-3p inhibits LCSC oncogenicity and cell stemness through HDAC7/PTEN axis. Inflammation Research, 1-11.

Guo, K., Ma, Z., Zhang, Y., Han, L., Shao, C., Feng, Y., ... & Yan, X. (2022). HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 91.

Axisa, P. P., Yoshida, T. M., Lucca, L. E., Kasler, H. G., Lincoln, M. R., Pham, G. H., ... & Hafler, D. A. (2022). A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Science Translational Medicine, 14(675), eabl3651.

Ye, J., Zhong, S., Deng, Y., Yao, X., Liu, Q., Wang, J. Z., & Xiao, S. (2022). HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. Molecular Neurobiology, 59(10), 6141-6157.

Ma, Z. Q., Feng, Y. T., Guo, K., Liu, D., Shao, C. J., Pan, M. H., ... & Hu, Y. (2022). Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Military Medical Research, 9(1), 54.

Hsu, A., Duan, Q., McMahon, S., Huang, Y., Wood, S. A., Gray, N. S., ... & Haldar, S. M. (2020). Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. The Journal of clinical investigation, 130(6), 2966-2977.

Wang, R., Zhang, H., Ding, W., Fan, Z., Ji, B., Ding, C., ... & Tang, H. (2020). miR-143 promotes angiogenesis and osteoblast differentiation by targeting HDAC7. Cell Death & Disease, 11(3), 179.

Caslini, C., Hong, S., Ban, Y. J., Chen, X. S., & Ince, T. A. (2019). HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells. Oncogene, 38(39), 6599-6614.

Daneshpajooh, M., Eliasson, L., Bacos, K., & Ling, C. (2018). MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation. Acta diabetologica, 55, 1231-1235.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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