Human Recombinant HDAC7, Active protein, GST Tag (V2LY-0526-LY4472)

Name: Human Recombinant HDAC7, Active protein, GST Tag
SKU: V2LY-0526-LY4472
Rating: 5 (1 reviews)

See all HDAC7 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant HDAC7, Active protein, GST Tag consist of Amino Acid: 501-end and predicts a molecular mass of 80 kDa.

Molecule Mass

80 kDa

Sequence

Amino Acid: 501-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Histone Deacetylase 7

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity).

May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565).

Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758).

In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758).

Biological Process

Cell-cell junction assembly Source: Ensembl
Chromatin organization Source: UniProtKB-KW
Negative regulation of interleukin-2 production Source: BHF-UCL
Negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
Negative regulation of osteoblast differentiation Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
Protein deacetylation Source: UniProtKB
Vasculogenesis Source: Ensembl

Cellular Location

Nucleus; Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

PTM

May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181.

Ramnath, D., Das Gupta, K., Wang, Y., Abrol, R., Curson, J. E., Lim, J., ... & Sweet, M. J. (2022). The histone deacetylase Hdac7 supports LPS-inducible glycolysis and Il-1β production in murine macrophages via distinct mechanisms. Journal of Leukocyte Biology, 111(2), 327-336.

Xu, C., Sun, W., Liu, J., Pu, H., & Li, Y. (2022). MiR-342-3p inhibits LCSC oncogenicity and cell stemness through HDAC7/PTEN axis. Inflammation Research, 1-11.

Guo, K., Ma, Z., Zhang, Y., Han, L., Shao, C., Feng, Y., ... & Yan, X. (2022). HDAC7 promotes NSCLC proliferation and metastasis via stabilization by deubiquitinase USP10 and activation of β-catenin-FGF18 pathway. Journal of Experimental & Clinical Cancer Research, 41(1), 91.

Axisa, P. P., Yoshida, T. M., Lucca, L. E., Kasler, H. G., Lincoln, M. R., Pham, G. H., ... & Hafler, D. A. (2022). A multiple sclerosis–protective coding variant reveals an essential role for HDAC7 in regulatory T cells. Science Translational Medicine, 14(675), eabl3651.

Ye, J., Zhong, S., Deng, Y., Yao, X., Liu, Q., Wang, J. Z., & Xiao, S. (2022). HDAC7 Activates IKK/NF-κB Signaling to Regulate Astrocyte-Mediated Inflammation. Molecular Neurobiology, 59(10), 6141-6157.

Ma, Z. Q., Feng, Y. T., Guo, K., Liu, D., Shao, C. J., Pan, M. H., ... & Hu, Y. (2022). Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability. Military Medical Research, 9(1), 54.

Hsu, A., Duan, Q., McMahon, S., Huang, Y., Wood, S. A., Gray, N. S., ... & Haldar, S. M. (2020). Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. The Journal of clinical investigation, 130(6), 2966-2977.

Wang, R., Zhang, H., Ding, W., Fan, Z., Ji, B., Ding, C., ... & Tang, H. (2020). miR-143 promotes angiogenesis and osteoblast differentiation by targeting HDAC7. Cell Death & Disease, 11(3), 179.

Caslini, C., Hong, S., Ban, Y. J., Chen, X. S., & Ince, T. A. (2019). HDAC7 regulates histone 3 lysine 27 acetylation and transcriptional activity at super-enhancer-associated genes in breast cancer stem cells. Oncogene, 38(39), 6599-6614.

Daneshpajooh, M., Eliasson, L., Bacos, K., & Ling, C. (2018). MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation. Acta diabetologica, 55, 1231-1235.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant HDAC7, Active protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

HDAC7 Matched Antibody Pair (535) (CAT#: APMAB-535LY)

HDAC7 Matched Antibody Pair (536) (CAT#: APMAB-536LY)

Antibody Pairs

HDAC7 Matched Antibody Pair (535) (CAT#: APMAB-535LY)

HDAC7 Matched Antibody Pair (536) (CAT#: APMAB-536LY)

Related Products

HDAC7 Matched Antibody Pair (536) (CAT#: APMAB-536LY)

Mouse Anti-HDAC7 Recombinant Antibody (9G369) (CAT#: CBMAB-H1812-FY)

Mouse Anti-HDAC7 Antibody (1A3) (CAT#: CBMAB-0444-YC)

HDAC7 Matched Antibody Pair (535) (CAT#: APMAB-535LY)

Mouse Anti-HDAC7 (AA 7-97) Monoclonal Antibody (CBFYH-3042) (CAT#: CBMAB-H1813-FY)

Mouse Anti-HDAC7 Recombinant Antibody (CBFYH-0888) (CAT#: CBMAB-H1816-FY)

Mouse Anti-HDAC7 Recombinant Antibody (CBFYH-0885) (CAT#: CBMAB-H0667-FY)

Rabbit Anti-HDAC7 Recombinant Antibody (E7O8V) (CAT#: CBMAB-CP0928-LY)

Rabbit Anti-HDAC7 Recombinant Antibody (CBFYH-0889) (CAT#: CBMAB-H1817-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry