Mouse Anti-HELQ Recombinant Antibody (8C113) (CBMAB-D2086-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Helicase, POLQ Like (HELQ). The antibody can be used for immunoassay techniques, such as WB.
See all HELQ antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

8C113

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Partial sequence of recombinant full-length protein to human DNA Helicase HEL308

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Helicase, POLQ Like

Introduction

HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase.

Entrez Gene ID

Human	113510
Mouse	191578
Rat	360912

UniProt ID

Human	Q8TDG4
Mouse	Q2VPA6
Rat	E9PT19

Alternative Names

Helicase, POLQ Like; Mus308-Like Helicase; POLQ-Like Helicase; HEL308; DNA Helicase HEL308; Helicase POLQ-Like; EC 3.6.4.12; EC 3.6.1;

Function

Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861).

Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).

Biological Process

Double-strand break repair via homologous recombination Source: UniProtKB
rRNA processing Source: GO_Central

Cellular Location

Nucleus

References

Jenkins, T., Northall, S. J., Ptchelkine, D., Lever, R., Cubbon, A., Betts, H., ... & Bolt, E. L. (2021). The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. NAR cancer, 3(1), zcaa043.

Jenkins, T., Northall, S., Bolt, E., & Soultanas, P. (2018). It's good to unwind: how Hel308/HelQ helicases are good for health. The Biochemist, 40(2), 32-36.

Long, J., Zhu, J. Y., Liu, Y. B., Fu, K., Tian, Y., Li, P. Y., ... & Zhang, Y. (2018). Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer. Gynecologic Oncology, 149(2), 341-349.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-HELQ Recombinant Antibody (D4K2O)

Mouse Anti-HELQ Recombinant Antibody (2406C1a)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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