Rabbit Anti-HELQ Recombinant Antibody (D4K2O) (CBMAB-CP0930-LY)

Name: Rabbit Anti-HELQ Recombinant Antibody (D4K2O)
SKU: CBMAB-CP0930-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

D4K2O

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1091 of human HELQ protein.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Helicase, POLQ Like

Introduction

HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

113510

UniProt ID

Q8TDG4

Alternative Names

Helicase; POLQ Like; Mus308-Like Helicase; POLQ-Like Helicase; HEL308; DNA Helicase HEL308; Helicase POLQ-Like; EC 3.6.4.12; EC 3.6.1;

Function

Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase (PubMed:11751861).

Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links (PubMed:19995904).

Biological Process

Double-strand break repair via homologous recombination Source: UniProtKB
rRNA processing Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Jenkins, T., Northall, S. J., Ptchelkine, D., Lever, R., Cubbon, A., Betts, H., ... & Bolt, E. L. (2021). The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core. NAR cancer, 3(1), zcaa043.

Jenkins, T., Northall, S., Bolt, E., & Soultanas, P. (2018). It's good to unwind: how Hel308/HelQ helicases are good for health. The Biochemist, 40(2), 32-36.

Long, J., Zhu, J. Y., Liu, Y. B., Fu, K., Tian, Y., Li, P. Y., ... & Zhang, Y. (2018). Helicase POLQ-like (HELQ) as a novel indicator of platinum-based chemoresistance for epithelial ovarian cancer. Gynecologic Oncology, 149(2), 341-349.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-HELQ Recombinant Antibody (2406C1a)

Mouse Anti-HELQ Recombinant Antibody (8C113)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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