Mouse Anti-HGFAC Recombinant Antibody (CBFYH-1036) (CBMAB-H1981-FY)

This product is mouse antibody that recognizes HGFAC. The antibody CBFYH-1036 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all HGFAC antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

CBFYH-1036

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Mouse, Rat, Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Hgf Activator

Introduction

This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	3083
Mouse	54426
Rat	58947

UniProt ID

Human	Q04756
Mouse	Q9R098
Rat	Q5EBA7

Alternative Names

HGF Activator; HGFA; Hepatocyte Growth Factor Activator; EC 3.4.21.-; EC 3.4.2

Function

Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form.

Biological Process

Blood coagulation Source: GO_Central
Proteolysis Source: GO_Central
Zymogen activation Source: GO_Central

Cellular Location

Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.

References

Sargsyan, A., Doridot, L., Hannou, S. A., Tong, W., Srinivasan, H., Ivison, R., ... & Herman, M. A. (2023). HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis. JCI insight, 8(1).

Banna, F. E., Otto, J. M., Mulloy, S. M., Tsai, W., McElroy, S. M., Wong, A. L., ... & Lee, A. M. (2022). Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Scientific reports, 12(1), 9336.

Sargsyan, A., Doridot, L., Hannou, S. A., Tong, W., Srinivasan, H., Ivison, R., ... & Herman, M. A. (2021). HGFAC is a ChREBP Regulated Hepatokine that Enhances Glucose and Lipid Homeostasis. bioRxiv, 2021-07.

Yin, L., Mu, Y., Lin, Y., & Xia, Q. (2019). HGFAC expression decreased in liver cancer and its low expression correlated with DNA hypermethylation and poor prognosis. Journal of Cellular Biochemistry, 120(6), 9692-9699.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-HGFAC Recombinant Antibody (CBFYH-1037)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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